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merck millipore,默克密理博,MABE191,Anti-WHSC1/NSD2 Antibody, clone 29D1
产品名称:Anti-WHSC1/NSD2 Antibody, clone 29D1
产品型号:MABE191
Detect WHSC1/NSD2 using this Anti-WHSC1/NSD2 Antibody, clone 29D1 validated for use in Western Blotting, Chromatin Immunoprecipitation (ChIP), Immunoprecipitation.
merck millipore,默克密理博,MABE191,Anti-WHSC1/NSD2 Antibody, clone 29D1
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ChIP, WB M Purified Monoclonal Antibody 描述 产品目录编号 MABE191 描述 Anti-WHSC1/NSD2 Antibody, clone 29D1 Alternate Names - Wolf-Hirschhorn syndrome candidate 1 protein
- Probable histone-lysine N-methyltransferase NSD2
- Multiple myeloma SET domain-containing protein
- Nuclear SET domain-containing protein 2
- Protein trithorax-5
背景信息 Wolf-Hirschhorn syndrome candidate 1 protein (WHSC1), Nuclear SET domain containing protein 2 (NSD2) is a histone lysine methyltransferase that is deregulated in a subgroup of multiple myelomas. NSD proteins have been described to serve as oncogenes; however, little is known about their targets in transcriptional repression or activation. NSD2 is overexpressed in multiple myelomas via translocation between the NSD2 locus on chromosome 4 and the immunoglobulin locus on chromosome 14. NSD2 is under the regulatory control of this immunoglobulin locus. Further research is required to elucidate its roles and mechanisms in cancer. 产品信息 格式 Purified 控制 - HCT116 cell lysate
演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect WHSC1/NSD2 using this Anti-WHSC1/NSD2 Antibody, clone 29D1 validated for use in Western Blotting, Chromatin Immunoprecipitation (ChIP), Immunoprecipitation. 主要应用 - Chromatin Immunoprecipitation (ChIP)
- Western Blotting
应用说明 Western Blot Analysis: 0.5-1 µg/mL from a representative lot detected WHSC1/NSD2 in 10 µg of HeLa nuclear extract and human placenta tissue lysate.
Chromatin Immunoprecipitation Analysis: A representative lot was used by an independent laboratory to detect WHSC1/NSD2 in transfected Gal4-reporter/293T cells. (Marango, J., et al. (2008). Blood. 111:3145-3154.)
Immunoprecipitation Analysis: A representative lot was used by an independent laboratory to detect WHSC1/NSD2 in KMS11 cells. (Marango, J., et al. (2008). Blood. 111:3145-3154.)生物信息 免疫原品种 GST-tagged recombinant protein corresponding to human WHSC1/NSD2. 克隆 29D1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2bκ 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001035889
基因符号 - TRX5
- WHSC1
- MMSET
- NSD2
纯化方法 Protein G purified UniProt编号 - O96028
产品使用声明 质量保证 Evaluated by Western Blot in HCT116 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected WHSC1/NSD2 in 10 µg of HCT116 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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