merck millipore,默克密理博,MABS199,Anti-Linear Ubiquitin, clone 1E3 Antibody

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merck millipore,默克密理博,MABS199,Anti-Linear Ubiquitin, clone 1E3 Antibody
产品名称：Anti-Linear Ubiquitin, clone 1E3 Antibody
产品型号：MABS199
This Anti-Linear Ubiquitin antibody, clone 1E3 is validated for use in western blotting, IP & ICC for the detection of Linear Ubiquitin.

merck millipore,默克密理博,MABS199,Anti-Linear Ubiquitin, clone 1E3 Antibody

产品介绍

merck millipore,默克密理博,MABS199,Anti-Linear Ubiquitin, clone 1E3 Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	ICC, WB	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	MABS199
描述	Anti-Linear Ubiquitin, clone 1E3 Antibody
Alternate Names	Ubiquitin Polyubiquitin-C
背景信息	Ubiquitin functions as a marker to indicate the fate of other proteins in the cell. It can be attached as a single molecule or as a polyubiquitin chain. Although ubiquitinated proteins are oftentimes tagged for degradation by the 20S proteosome, ubiquitination can also indicate alternative fates depending on the lysine residue that is involved in linking the ubiquitin chain to the target protein. Ubiquitin chains linked by Lys33 to kinase substrates such as AMP-activated protein kinases, (AMPKα1, BRSK1, MARK3, MARK4, and NUAK1), may activate or deactivate these proteins, supporting the role for uniquitin in regulating signaling.

产品信息
格式	Purified
演示	Purified rabbit monoclonal IgGκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	This Anti-Linear Ubiquitin antibody, clone 1E3 is validated for use in western blotting, IP & ICC for the detection of Linear Ubiquitin.
主要应用	Immunocytochemistry Western Blotting
应用说明	Immunocytochemistry Analysis: A 1:50 dilution from a representative lot detected linear ubiquitin in Hoi-1L/Hoip transfected Hela cells. Immunoprecipitatation Analysis: 10 µg from a representative lot immunoprecipitated linear ubiquitin from 500 µg of Hoi-1L/Hoip transfected HEK293 cells. Western Blotting Analysis: A representative lot from an independent laboratory detected K64-linked diUbiquitin (Matsumoto, M. L., et al. (2012). J Mol Biol. 418(3-4):134-144.).

生物信息
免疫原品种	Recombinant protein corresponding to all linear ubiquitin linkages.
克隆	1E3
宿主	Rabbit
同种型	IgGκ
品种反应性	Human
抗体类型	Monoclonal Antibody
基因符号	UBC
纯化方法	Protein A purified
UniProt编号	P0CG48

产品使用声明
质量保证	Evaluated by Western Blotting in linear polyubiquitin chains, K48 Ubiquitin 2-7, K63 Ubiquitin 2-7, and K11-only Ubn-ubiquitinylated HM substrate protein synthesized using K11-only mutant ubiquitin. Western Blotting Analysis: A 1:1,000 dilution of this antibody detected linear ubiquitin chains, and not K48 Ubiquitin 2-7, K63 Ubiquitin 2-7, or K11-only Ubn-ubiquitinylated HM substrate protein synthesized using K11-only mutant ubiquitin.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品使用声明

质量保证

Evaluated by Western Blotting in linear polyubiquitin chains, K48 Ubiquitin 2-7, K63 Ubiquitin 2-7, and K11-only Ubn-ubiquitinylated HM substrate protein synthesized using K11-only mutant ubiquitin.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected linear ubiquitin chains, and not K48 Ubiquitin 2-7, K63 Ubiquitin 2-7, or K11-only Ubn-ubiquitinylated HM substrate protein synthesized using K11-only mutant ubiquitin.

使用声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.