merck millipore,默克密理愽
  • merck millipore,默克密理博,MABC86,Anti-Nesprin-2 Antibody, clone K20-478

  • merck millipore,默克密理博,MABC86,Anti-Nesprin-2 Antibody, clone K20-478

    产品名称：Anti-Nesprin-2 Antibody, clone K20-478
    产品型号：MABC86
    Detect Nesprin-2 using this mouse monoclonal antibody, Anti-Nesprin-2 Antibody, clone K20-478 validated for use in western blotting, ICC & IP.

    merck millipore,默克密理博,MABC86,Anti-Nesprin-2 Antibody, clone K20-478

  • 产品介绍
  • merck millipore,默克密理博,MABC86,Anti-Nesprin-2 Antibody, clone K20-478

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABC86
    描述 Anti-Nesprin-2 Antibody, clone K20-478
    Alternate Names
    • Syne-2
    • Nesprin-2
    • Nuclear envelope spectrin repeat protein 2
    • Nucleus and actin connecting element protein
    • Protein NUANCE
    • Synaptic nuclear envelope protein 2
    背景信息 Nesprin-2 (SYNE-2) is also known as Nuclear envelope spectrin repeat protein 2 or Nucleus and actin connecting element protein, and it functions to network organelles and the actin cytoskeleton in order maintain subcellular spatial organization. Nesprin-2 connects nuclei to the cytoskeleton by interacting with the nuclear envelope and cytoplasmic F-actin, and is required for centrosome migration to the apical cell surface during early ciliogenesis. Nesprin-2 is widely expressed, with high levels seen in kidney, adult and fetal liver, stomach and placenta. Defects in SYNE2 are responsible for Emery-Dreifuss muscular dystrophy type 5 (EDMD5).
    产品信息
    格式 Purified
    演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect Nesprin-2 using this mouse monoclonal antibody, Anti-Nesprin-2 Antibody, clone K20-478 validated for use in western blotting, ICC & IP.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: A 1:50 dilution of this antibody detected Nesprin-2 in HepG2 and COS-7 cells.

    Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated Nesprin-2 in HA-MKS3 transfected HEK293 whole cell extracts. Immunoprecipitated sample was then subjected to Western Blotting using the same representative lot of antibody (Dawe, H. R., et al. (2009). J Cell Sci. 122(Pt 15): 2716-2626.).

    Western Blotting Analysis: A representative lot from an independent laboratory detected Nesperin-2 in IMCDE whole cell extracts. High levels of a 25 kDa ABD-containing isoform was observed only at post-confluence (+72 hours); however, a second major ABD-containing isoform was observed at 55 kDa before and after confluence (Dawe, H. R., et al. (2009). J Cell Sci. 122(Pt 15): 2716-2626.).

    Dylight® is a registered trademark of Thermo Fisher Scientific. Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
    生物信息
    免疫原品种 His-tagged recombinant protein corresponding to human Nesprin-2.
    克隆 K20-478
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG2bκ
    品种反应性 MouseHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_055995
    基因符号
    • NUA
    • SYNE2
    纯化方法 Protein G purified
    UniProt编号
    • Q8WXH0
    产品使用声明
    质量保证 Evaluated by Western Blotting in COS-7 cell lysate.

    Western Blotting Analysis: 0.5 µg/mL of this antibody detected Nesprin-2 in 10 µg of COS-7 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABC86,Anti-Nesprin-2 Antibody, clone K20-478

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