merck millipore,默克密理博,373273,Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7

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Merck Millipore 默克密理愽

merck millipore,默克密理博,373273,Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem

经验配方	CAS号
C₂₆H₂₆ClN₃O₄	329196-48-7

描述
概述	A nanomolar Smoothened (smo) antagonist that exhibits 2.3- and 6-fold weaker biological activity than SANT-1 (Cat. No. 559303), respectively, in antagonizing ShhNp- and SAG-stimulated hedgehog pathway activation in HEK 293-based (Shh-LIGHT2) reporter assays. Competitive binding studies show full replacement of Smo-bound cyclopamine (Cat. No. 239803) by SANT-1 and SANT-2 (K_i = 2.4 and 8.4 nM, respectively), while SANT-1 and SANT-2 are shown to compete against Smo-bound SAG-1.3 (Cat. Nos. 566660 & 566661) in an allosteric manner and that only SANT-2, but not SANT-1, is able to completely compete off bound SAG-1.3 (100% vs. 40% replacement by the respective compound at 10 µM).
产品目录编号	373273
品牌系列	Calbiochem®
同义词	N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-tris(ethyloxy)benzamide, Smo Antagonist V

参考
参考	Rominger, C.M., et al. 2009. J. Pharmacol. Exp. Ther. 329, 995. Rohatgi, R., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 3196. Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.

生物信息
纯度	≥95% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,373273,Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem

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