merck millipore,默克密理博,MABC685,Anti-ENC1 Antibody, clone EPR5406(B), rabbit monoclonal

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

当前位置：首页 > >Merck Millipore > 生命科学研究
生命科学研究

merck millipore,默克密理博,MABC685,Anti-ENC1 Antibody, clone EPR5406(B), rabbit monoclonal
产品名称：Anti-ENC1 Antibody, clone EPR5406(B), rabbit monoclonal
产品型号：MABC685
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.

merck millipore,默克密理博,MABC685,Anti-ENC1 Antibody, clone EPR5406(B), rabbit monoclonal

产品介绍

merck millipore,默克密理博,MABC685,Anti-ENC1 Antibody, clone EPR5406(B), rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	MABC685
描述	Anti-ENC1 Antibody, clone EPR5406(B), rabbit monoclonal
Alternate Names	p53-induced gene 10 protein Ectoderm-neural cortex protein 1 ENC-1 Kelch-like protein 37 Nuclear matrix protein NRP/B
背景信息	Ectoderm-neural cortex protein 1 (ENC1) as its name suggests is a protein involved in the regulation and differentiation of neural crest cells and neuronal development, as well as a protein involved in neuronal process formation later on. It is also known as nuclear matrix protein NRP/B. It is an actin binding protein that appears important in the organization of the actin cytoskeleton during neural fate specification and nervous system development. Its role in neuronal process formation is via its binding of RB1 (p110RB) when it is hypophosophorylated. ENC1 is widely expressed during development in the fetal heart, lung, and kidney. In the adult ENC1 is more restricted to nervous tissues primarily. It is abundant in adult brain, hippocampus, amygdale and spinal cord. There is also expression found in the adult pancreas. Numerous neuronal cancer cell lines and primary brain tumors also express ENC1. Localization is nuclear for the most part but in some cancer cells cytoplasmic staining is also observed. Its role in tumors is as an oncogene as studies suggest that both amplification and alteration of ENC1 may lead to tumor development and growth. Moreover ENC1 plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation as well. EMD-Millipore’s Anti-ENC1 rabbit monoclonal antibody, clone EPR5406 (B) has been tested by western blot in human fetal brain lysates and in immunohistochemistry in paraffin embedded human brain tissue.

产品信息
格式	Unpurified
控制	Human fetal brain tissue lysate
演示	Rabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A 1:100-250 dilution from a representative lot detected ENC1 in human brain tissue. Optimal working dilutions must be determined by end user.

生物信息
免疫原品种	Synthetic peptide corresponding to human ENC1.
克隆	EPR5406(B)
宿主	Rabbit
品种反应性	Human
抗体类型	Monoclonal Antibody
基因符号	PIG10 ENC1 KLHL37 NRPB
纯化方法	Unpurified
UniProt编号	O14682

产品使用声明
质量保证	Evaluated by Western Blotting in human fetal brain tissue lysate. Western Blotting Analysis: A 1:1,000- 10,000 dilution of this antibody detected ENC1 in human fetal brain tissue lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.