- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
描述 产品目录编号 14-634 品牌系列 Upstate
商名 - Upstate
描述 MuSK Protein, active, 10 µg 概述 N-terminal His6-tagged, recombinant, human MuSK 应用 应用 Active, N-terminal His6-tagged, recombinant, human MuSK, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 human MuSK, amino acids 530-end, expressed by baculovirus in Sf21 cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_005592.1
Entrez基因汇总 Intercellular communication is often mediated by receptors on the surface of one cell that recognize and are activated by specific protein ligands released by other cells. Members of one class of cell surface receptors, receptor tyrosine kinases (RTKs), are characterized by having a cytoplasmic domain containing intrinsic tyrosine kinase activity. This kinase activity is regulated by the binding of a cognate ligand to the extracellular portion of the receptor. DeChiara et al. (1996) [PubMed 8653786] noted that the RTKs, known to be expressed in cell type-specific fashions, play a role critical for the growth and differentiation of those cell types. For example, members of the neural-specific TRK family that recognize nerve growth factor are absolutely required for the survival and development of discrete neuronal subpopulations, and the receptor tyrosine kinases TIE1 (MIM 600222) and TIE2 (MIM 600221) play a critical role in the development of normal blood vessels.[supplied by OMIM] 基因符号 - MGC126324
- MUSK
- MuSK
- MGC126323
蛋白靶 MuSK 纯化方法 Ni2+/NTA-agarose 靶子系列 TK UniProt编号 - O15146
UniProt汇总 FUNCTION: SwissProt: O15146 # Receptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization (By similarity).
SIZE: 869 amino acids; 97056 Da
SUBUNIT: Interacts with DOK7, which probably regulates its activity (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
DISEASE: SwissProt: O15146 # Defects in MUSK is a cause of autosomal recessive congenital myasthenic syndrome (CMS) [MIM:608931]. Congenital myasthenic syndromes are inherited disorders of neuromuscular transmission that stem from mutations in presynaptic, synaptic, or postsynaptic proteins. MUSK mutations lead to decreased agrin- dependent AChR aggregation, a critical step in the formation of the neuromuscular junction.
SIMILARITY: SwissProt: O15146 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. & Contains 1 FZ (frizzled) domain. & Contains 3 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of MBP (13-104) 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C 包装信息 数量 10 µg
上一件merck millipore产品：merck millipore,默克密理博,AP130F,Goat Anti-Mouse IgG & IgM Antibody, FITC conjugate
下一件merck millipore产品：merck millipore,默克密理博,390602,Hydroxyfasudil - CAS 155558-32-0 - Calbiochem
相关产品
merck millipore,默克密理博,SF-451,miR-181a-5p; Human, Cyanine 5, RNA Detection Probe,SmartFlare
merck millipore,默克密理博,MABC685,Anti-ENC1 Antibody, clone EPR5406(B), rabbit monoclonal
merck millipore,默克密理博,06-667,Anti-JAK3 Antibody, CT
merck millipore,默克密理博,SF-1214,PARK2; Ms, Cyanine 3 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,AP130F,Goat Anti-Mouse IgG & IgM Antibody, FITC conjugate
merck millipore,默克密理博,390602,Hydroxyfasudil - CAS 155558-32-0 - Calbiochem
merck millipore,默克密理博,567692,L(-)Sorbose - CAS 87-79-6 - Calbiochem
merck millipore,默克密理博,SF-840,miR-28-5p; Human, Cyanine 3, RNA Detection Probe,SmartFlare
merck millipore,默克密理博,HTS136RTA,Ready-to-Assay™ V1B Vasopressin Receptor Frozen Cells
