merck millipore,默克密理愽
  • merck millipore,默克密理博,390602,Hydroxyfasudil - CAS 155558-32-0 - Calbiochem

  • merck millipore,默克密理博,390602,Hydroxyfasudil - CAS 155558-32-0 - Calbiochem

    产品名称：Hydroxyfasudil - CAS 155558-32-0 - Calbiochem
    产品型号：390602
    A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties.

    merck millipore,默克密理博,390602,Hydroxyfasudil - CAS 155558-32-0 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,390602,Hydroxyfasudil - CAS 155558-32-0 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₄H₁₇N₃O₃S • HCl155558-32-0
    描述
    概述 A cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil; Cat. No. 371970) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rho-kinase (IC50 = 0.9 and 1.8 µM using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKβ, and PKC. Reported to inhibit the Rho kinase-mediated contraction both in vitro and in vivo.
    产品目录编号 390602
    品牌系列 Calbiochem®
    同义词 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine, HCl, HA1100, ROCK Inhibitor XIV
    参考
    参考 Ito, K., et al. 2003. J. Physiol. 546, 823.
    Takemoto, M., et al. 2002. Circulation 106, 57.
    Shimokawa, H., et al. 1999. Cardiovasc. Res. 43, 1029.
    产品信息
    CAS号 155558-32-0
    具有ATP竞争性 Y
    形式 Liquid
    配方 A 10 mM (2 mg/582 µl) solution in H₂O.
    Hill配方 C₁₄H₁₇N₃O₃S • HCl
    化学配方 C₁₄H₁₇N₃O₃S • HCl
    Molar Mass 343.8
    可逆 Y
    结构配方图像
    生物信息
    主靶 Rho-kinase
    主靶IC50 0.9 and 1.8 µM against Rho-kinase using a peptide and MLC as substrate, respectively
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    储存和货运信息
    货运代码 Blue Ice Only
    毒性 Harmful
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following initial thaw, aliquot and freeze (-20°C).
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,390602,Hydroxyfasudil - CAS 155558-32-0 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,14-634,MuSK Protein, active, 10 µg
下一件merck millipore产品：merck millipore,默克密理博,567692,L(-)Sorbose - CAS 87-79-6 - Calbiochem


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