merck millipore,默克密理博,MABC171,Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132H Antibody, clone HMab-1

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	ICC, WB, IHC	M	Purified	Monoclonal Antibody

描述
产品目录编号	MABC171
描述	Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132H Antibody, clone HMab-1
Alternate Names	Oxalosuccinate decarboxylase Isocitrate dehydrogenase [NADP] cytoplasmic IDH Cytosolic NADP-isocitrate dehydrogenase IDP NADP(+)-specific ICDH
背景信息	Isocitrate dehydrogenase 1 (IDH1) is a 46 kDa NADP-dependent enzyme, which catalyzes the decarboxylation of isocitrate into α-ketoglutarate. IDH1 may also play a role in the prevention of oxidative damage, and the shuttling of proteins to peroxisomes. It is widely reported that mutations in IDH1 result in various types of glioma.

产品信息
格式	Purified
控制	MBP tagged recombinant Isocitrate Dehydrogenase 1 (IDH1)
演示	Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Detect Isocitrate Dehydrogenase 1 (IDH1)-R132H using this Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132H Antibody, clone HMab-1 validated for use in Western Blotting, IHC, ICC.
主要应用	Immunocytochemistry Western Blotting Immunohistochemistry
应用说明	Western Blot Analysis: A representative lot of this antibody detected Isocitrate Dehydrogenase 1 (IDH1)-R132S in a panel of wild-type and mutated recombinant IDH1 proteins. Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Isocitrate Dehydrogenase 1 (IDH1)-R132S in anaplastic and diffuse astrocytoma tissues and in primary glioblastoma tissues (Kato, Y., et al. (2009). Biochem Biophys Res Commun. 390(3):547-51.). Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Isocitrate Dehydrogenase 1 (IDH1)-R132S in transfected glioblastoma and transfected LN229 cells (Kaneko, M. K., et al. (2011). Biochem Biophys Res Commun. 406(4):608-613.).

生物信息
免疫原品种	KLH-conjugated linear peptide corresponding to human Isocitrate Dehydrogenase 1 (IDH1).
克隆	HMab-1
宿主	Mouse
特异性	This antibody is specific for the R132H mutation of Isocitrate Dehydrogenase 1 (IDH1).
同种型	IgG1κ
品种反应性	Human
Species Reactivity Note	Demonstrated to react with Human.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_005887
基因符号	PICD IDH1
纯化方法	Protein G purified
UniProt编号	O75874

产品使用声明
质量保证	Evaluated by Western Blot in MBP-tagged recombinant Isocitrate Dehydrogenase 1 (IDH1). Western Blot Analysis: A 1:500 dilution of this antibody detected MBP tagged recombinant Isocitrate Dehydrogenase 1 (IDH1) in WB.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	200 µL

merck millipore,默克密理博,MABC171,Anti-Isocitrate Dehydrogenase 1 (IDH1)-R132H Antibody, clone HMab-1

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