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merck millipore,默克密理博,569393,Stauprimide - CAS 154589-96-5 - Calbiochem
产品名称：Stauprimide - CAS 154589-96-5 - Calbiochem
产品型号：569393
A cell-permeable ESCs (Embryonic Stem Cells) EMT (Epithelial-Mesenchymal Transition) inducer that is reported to prime/sensitize human and murine ESC cultures for much more enhanced/efficient differen More>>
merck millipore,默克密理博,569393,Stauprimide - CAS 154589-96-5 - Calbiochem
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重要规格表
经验配方 CAS号 C₃₅H₂₈N₄O₅ 154589-96-5 描述 概述 A cell-permeable ESCs (Embryonic Stem Cells) EMT (Epithelial-Mesenchymal Transition) inducer that is reported to prime/sensitize human and murine ESC cultures for much more enhanced/efficient differentiation into progenitor cells of multiple lineages, including Activin A- (Cat. No. 114700) induced definitive endoderm differentiation (60% differentiation from murine R1 ESCs with 5 ng/ml Activin A and 200 nM Spd), ATRA- (Cat. No. 554720) induced neuronal progenitor differentiation, and BMP-4- (Cat. No. 203642) induced mesoderm differentiation, under suboptimal lineage specifying stimuli concentrations and often serum-free conditions, while Spd sensitization alone does not induce any ESCs differentiation. Spd is shown to interact with NME2/DNPK B/PUF and prevent NME2 nuclear localization and c-myc transcription in murine R1 ESC cultures (46% and 85% drop in c-myc mRNA in 24 h, respectively, with 200 nM and 500 nM Spd), which accounts for, at least in part, its EMT induction activity. Although a structural analog of the broad-spectrum kinase inhibitors Staurosporine (Cat. Nos. 569396 and 569397) and UCN-01 (Cat. No. 539644), Spd exhibits significant kinase inhibitory activities only at elevated concentrations, but not at concentrations ≤500 nM typically used in EMT induction. 产品目录编号 569393 品牌系列 Calbiochem®
同义词 Spd, ESC EMT Inducer 参考 参考 Zhu, S., et al. 2009. Cell Stem Cell 4, 416. 产品信息 CAS号 154589-96-5 形式 Yellow solid Hill配方 C₃₅H₂₈N₄O₅ 化学配方 C₃₅H₂₈N₄O₅ Molar Mass 584.6 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO or EtOH 安全信息 S相 S: 22-24/25
Do not breathe dust.
Avoid contact with skin and eyes.储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliqout and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C. 包装信息 惰性气体下包装 Packaged under inert gas
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