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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, ELISA, WB, ICC M Ascites Monoclonal Antibody 描述 产品目录编号 MAB8991 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-LASP-1 Antibody, clone 8C6 Alternate Names - LIM and SH3 Domain Protein 1
背景信息 Lasp-1 is an actin-binding scaffolding protein that is overexpressed in 8-12% of breast cancers and is correlated to increased incidences of metastasis. Lasp-1 localizes to newly forming focal adhesions and membrane ruffles during cell migration. 产品信息 格式 Ascites 演示 Ascites fluid. Liquid containing no preservatives. 应用 应用 Anti-LASP-1 Antibody, clone 8C6 is an antibody against LASP-1 for use in ELISA, IP, WB, IC, IH. 主要应用 - Immunohistochemistry
- ELISA
- Western Blotting
- Immunocytochemistry
应用说明 Immunohistochemistry (frozen sections): 1:200
Immunocytochemistry: 1:200
Western blot: 1:2,000
Immunoprecipitation: 1:250-1:1,000
Indirect ELISA: 1:1,000
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide corresponding to an internal sequence of human Lasp-1. 克隆 8C6 宿主 Mouse 特异性 Recognizes human Lasp-1 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_006148.1
Entrez基因汇总 This gene encodes a member of a LIM protein subfamily which is characterized by a LIM motif and a domain of Src homology region 3. This protein functions as an actin-binding protein and possibly in cytoskeletal organization. 基因符号 - Lasp-1
- LASP1
- LASP-1
- MLN50
UniProt编号 - Q14847
UniProt汇总 FUNCTION: SwissProt: Q14847 # Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).
SIZE: 261 amino acids; 29717 Da
SUBUNIT: Interacts with F-actin (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cell cortex (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associated with the F-actin rich cortical cytoskeleton (By similarity).
PTM: Phosphorylated (By similarity).
SIMILARITY: SwissProt: Q14847 ## Contains 1 LIM zinc-binding domain. & Contains 2 nebulin repeats. & Contains 1 SH3 domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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