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品种反应性 主要应用 宿主 格式 抗体类型 R WB M Ascites Monoclonal Antibody 描述 产品目录编号 MAB5574 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-NMDAR2B Antibody 产品信息 格式 Ascites 控制 - Rat forebrain or cerebellum.
演示 Liquid 应用 应用 Detect NMDAR2B using this Anti-NMDAR2B Antibody validated for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 1:1,000-1:5,000 on rat brain lysate.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Recombinant protein from rat NMDAR2B. 克隆 1B3.3B6 宿主 Mouse 特异性 NMDAR2B, C-terminal. By Western blot the antibody reacts with bands at ~170 and ~90 kDa on rat brain lysate. 同种型 IgG1 品种反应性 Rat 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000834.2
Entrez基因汇总 N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. 基因符号 - hNR3
- GRIN2B
- MGC142180
- Glutamate
- NMDAR2B
- NR3
- NR2B
- MGC142178
UniProt编号 - Q13224
UniProt汇总 FUNCTION: SwissProt: Q13224 # NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
SIZE: 1484 amino acids; 166367 Da
SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4 (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.
SIMILARITY: SwissProt: Q13224 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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