merck millipore,默克密理愽
  • merck millipore,默克密理博,681637,Wee1/Chk1 Inhibitor - CAS 1177150-89-8 - Calbiochem

  • merck millipore,默克密理博,681637,Wee1/Chk1 Inhibitor - CAS 1177150-89-8 - Calbiochem

    产品名称：Wee1/Chk1 Inhibitor - CAS 1177150-89-8 - Calbiochem
    产品型号：681637
    The Wee1/Chk1 Inhibitor, also referenced under CAS 1177150-89-8, controls the biological activity of Wee1/Chk1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation  More>>

    merck millipore,默克密理博,681637,Wee1/Chk1 Inhibitor - CAS 1177150-89-8 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,681637,Wee1/Chk1 Inhibitor - CAS 1177150-89-8 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₁₂N₂O₃ • H₂O1177150-89-8
    描述
    概述 A pyrrolocarbazole compound that acts as a potent and ATP-competitive inhibitor of checkpoint kinases Wee1 and Chk1 (IC50 = 97 nM and 47 nM, respectively). Inhibits PKC, Cdk4, or other CDKs only at much higher concentrations (IC50 = 3.4 µM, 3.75 µM, and >5 µM, respectively) and exhibits little effect against FGFR, PDGFR, or c-Src (IC50 >50 µM).
    产品目录编号 681637
    品牌系列 Calbiochem®
    同义词 4-(2-Phenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor IV, Wee1 Inhibitor III
    参考
    参考 Palmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.
    Squire, C.J., et al. 2005. Structure 13, 541.
    产品信息
    CAS号 1177150-89-8
    具有ATP竞争性 Y
    形式 Orange solid
    Hill配方 C₂₀H₁₂N₂O₃ • H₂O
    化学配方 C₂₀H₁₂N₂O₃ • H₂O
    Molar Mass 346.3
    可逆 N
    结构配方图像
    生物信息
    主靶 Wee1 and Chk1
    主靶IC50 97 nM and 47 nM against Wee1 and Chk1, respectively
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 N
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,681637,Wee1/Chk1 Inhibitor - CAS 1177150-89-8 - Calbiochem

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