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描述 概述 Recombinant, human PAK1 fused at the N-terminus to a GST-His6-thrombin cleavage site sequence and expressed in S. frugiperda insect cells using a baculovirus expression system. PAK1 is a serine/threonine kinase that interacts with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Phosphorylation at Thr423 by PDK activates PAK1. It is known as an important modulator of cytoskeletal reorganization and GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. 产品目录编号 325889 品牌系列 Calbiochem®
同义词 PAK1 参考 参考 Singh, R.R., et al. 2005. J. Biol. Chem. 280 18130.
Chen, S., et al. 2003. J. Biol. Chem. 278, 20029.
Sells, M.A., et al. 1997. Curr. Biol. 7, 202.产品信息 EC号 2.7.1.37 形式 Liquid 配方 In 100 mM NaCl, 50 mM Tris-HCl, 5 mM DTT, 4 mM reduced glutathione, 20% glycerol, pH 8.0. Molar Mass 90542 生物信息 特异活性 ≥325 U/mg protein 浓缩标签 Please refer to vial label for lot-specific concentration
储存和货运信息 货运代码 Dry Ice Only
毒性 Standard Handling
储存 ≤ -70°C
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C).
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