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- merck millipore,默克密理博,MAB5364A4,Anti-Reelin Antibody, clone G10, Alexa Fluor 488 Conjugate,MAB5364A4
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, M IHC, ICC M AlexaFluor®488 Monoclonal Antibody 描述 产品目录编号 MAB5364A4 描述 Anti-Reelin Antibody, clone G10, Alexa Fluor® 488 Conjugate | MAB5364A4 Alternate Names - Reelin
背景信息 Reelin, a glycoprotein, plays a crucial role during embryonic neuronal migration, primarily as a regulator of corticogenesis and neuronal cell positioning in the prenatal period. In adults, reelin may act as a modulator of synaptic plasticity. Reelin has been implicated to play a role in several brain diseases including schizphrenia, Alzheimers's disease, temporal lobe epilespy, and autism. Reelin is found in the brain, spinal cord, blood, and other body organs and tissues. 产品信息 格式 AlexaFluor®488 控制 - Adult mouse brain tissue
演示 Purified mouse monoclonal IgG1 conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 主要应用 - Immunohistochemistry
- Immunocytochemistry
应用说明 Immunocytochemistry Analysis: A 1:400 dilution from a representative lot detected Reelin in rat E18 primary cortex cells. 生物信息 免疫原品种 Recombinant protein corresponding to rat Reelin. 宿主 Mouse 同种型 IgG 品种反应性 RatMouse Species Reactivity Note Demonstrated to react with Mouse and Rat. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_536319
Entrez基因汇总 This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. 基因符号 - Reln
纯化方法 Protein A purified UniProt编号 - P58751
UniProt汇总 FUNCTION: Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and ApoER2 induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).
SIZE: 3460 amino acids; 388402 Da
SUBUNIT: Binds to the ectodomains of VLDLR and ApoER2 (By similarity).
SUBCELLULAR LOCATION: Secreted (By similarity).
TISSUE SPECIFICITY: Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. In adult brain, preferentially expressed in GABAergic interneurons of prefrontal cortices, temporal cortex, hippocampus and glutamatergic granule cells of cerebellum. Also expressed in fetal and adult liver.DEVELOPMENTAL STAGE: Expressed in fetal and postnatal brain and liver. Expression in postnatal human brain is high in the cerebellum.
DOMAIN: The basic C-terminal region is essential for secretion (By similarity).
DISEASE: Defects in RELN are the cause of autosomal recessive lissencephaly with cerebellar hypoplasia [MIM:257320]; also known as Norman-Roberts syndrome. Some patients also displayed persistent lymphedema neonatally, and one showed accumulation of chlyous or fatty, ascites fluid. & Defects in RELN may contribute to susceptibility to schizophrenia. Expression of the protein is reduced to about 50% in patients with schizophrenia. & Defects in RELN may predispose to autistic disorder. A polymorphic GGC triplet repeat located in the 5'-UTR region of RELN gene, which harbors in the normal population 8 to 10 repeats, is significantly increased in autistic patients to carry 4 to 23 additional repeats.
SIMILARITY: Belongs to the reelin family. & Contains 15 BNR repeats. & Contains 8 EGF-like domains. & Contains 1 reelin domain.产品使用声明 质量保证 Evaluated by Immunohistochemistry in adult mouse brain tissue.
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Reelin in adult mouse brain tissue.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 µL
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