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品种反应性 主要应用 宿主 格式 抗体类型 H FC Rb FITC Polyclonal Antibody 描述 产品目录编号 FCABS350F 商名 - Milli-Mark
描述 Milli-Mark™ Anti-TrkA-FITC Antibody Alternate Names - neurotrophic tyrosine kinase, receptor, type 1
- Neurotrophic tyrosine kinase receptor type
- Oncogene TRK
- TRK1-transforming tyrosine kinase protein
- high affinity nerve growth factor receptor
背景信息 TrkA is a high affinity nerve growth factor (NGF). The Trk proto-oncogene family contains four members, TrkA, TrkB, TrkC, and TrkE, which are variably expressed throughout the central and peripheral nervous systems. TrkA binds to nerve growth factor (NGF) and autophosphorylates on tyrosine residues (Tyr490, Tyr674, Tyr675, Tyr751 and Tyr785) to activate multiple downstream effector proteins. Phosphorylation at Tyr490 is required for Shc association and subsequent activation of the Ras-MAP kinase-signaling cascade, which leads to activation of Elk-1-dependent gene transcription and neurite growth. Phosphorylations at Tyr674 and Tyr675 lie within the catalytic domain of TrkA tyrosine kinase and reflect Trk kinase activity. Additionally, phosphorylation at Tyr751 is required for PI3-kinase association and activation of the Akt signaling cascade. 产品信息 格式 FITC 控制 - HeLa cells
演示 Purified rabbit polyclonal IgG conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 应用 Detect TrkA using this Milli-Mark Anti-TrkA-FITC Antibody validated for use in FC. 主要应用 - Flow Cytometry
生物信息 免疫原品种 Bacterially expressed purified protein corresponding to the entire extracellular domain of rat TrkA receptor. 表位 Extracellular domain 宿主 Rabbit 特异性 Antibody recognizes TrkA protein. 同种型 IgG 品种反应性 Human Species Reactivity Note Tested and passed on Human. Unconjugated version Cat.No.06-574 is predicted to react with Rat based on immunogen design. The unconjugated part number was also shown to react with Mouse. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_067600
基因符号 - TRK
- DKFZp781I14186
- EC 2.7.10.1
- MTC
- OTTHUMP00000038736
纯化方法 Protein A Purified UniProt编号 - P35739
UniProt汇总 Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway 产品使用声明 质量保证 Evaluated by flow cytometry using HeLa cells. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 tests
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