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  • merck millipore,默克密理博,AB5484,Anti-RAGE Antibody

  • merck millipore,默克密理博,AB5484,Anti-RAGE Antibody

    产品名称：Anti-RAGE Antibody
    产品型号：AB5484
    Detect RAGE using this Anti-RAGE Antibody validated for use in ELISA, IH(P).

    merck millipore,默克密理博,AB5484,Anti-RAGE Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5484,Anti-RAGE Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HELISAGtSerumPolyclonal Antibody
    描述
    产品目录编号 AB5484
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-RAGE Antibody
    Alternate Names
    • Receptor for Advanced Glycosylation End Products
    背景信息 RAGE is a member of the immunoglobulin superfamily of cell surface molecules that binds molecules that have been irreversibly modified by non-enzymatic glycation and oxidation, and are know as advanced glycation end products (AGEs). It is expressed by endothelium, mononuclear phagocytes, neurons and smooth muscle cells. Whereas RAGE is present at high levels during development, especially in the central nervous system, its levels decline during maturity.The increased expression of RAGE is associated with several pathological states, such as diabetic vasculopathy, neuropathy, retinopathy and other disorders, including Alzheimer's disease and immune/inflammatory reactions of the vessel walls. In diabetic tissues, the production of RAGE is due to the overproduction of AGEs that eventually overwhelm the protective properties of RAGE. This results in oxidative stress and endothelial cell dysfunction that leads to vascular disease in diabetics. In the brain, RAGE also binds amyloid beta (Ab). Because Ab is overproduced in neurons and vessels in the brains of Alzheimer disease, this leads to the hyperstimulation of RAGE. The RAGE-Ab interaction is thought to result in oxidative stress leading to neuronal degeneration.
    产品信息
    格式 Serum
    演示 Goat serum. Liquid containing 0.01% thimerosal.
    应用
    应用 Detect RAGE using this Anti-RAGE Antibody validated for use in ELISA, IH(P).
    主要应用
    • ELISA
    应用说明 Immunohistochemistry on formalin fixed, paraffin embedded tissue sections: = 1:400. The antibody reacts well with human diabetic kidney. The antibody may show better reactivity after performing antigen retrieval by the citrate buffer/pressure cooker method.

    ELISA against immunogen peptide: = 1:260,000

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide that corresponds to amino acids 42-59 of the human receptor for advanced glycated end products.
    宿主 Goat
    特异性 Specific for receptor for advanced glycosylation end products (RAGE). This antibody immunolabels vessels from diabetic tissues and vessels and neurons from the brains of Alzheimer's Disease (AD) patients in formalin-fixed paraffin sections.
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_014226.1
    基因符号
    • EC 2.7.11.22
    • RAGE
    • RAGE-1
    • MOK
    • RAGE1
    UniProt编号
    • Q9UQ07
    UniProt汇总 FUNCTION: SwissProt: Q9UQ07 # Able to phosphorylate several exogenous substrates and to undergo autophosphorylation (By similarity).
    SIZE: 419 amino acids; 48014 Da
    SUBCELLULAR LOCATION: Cytoplasm (By similarity).
    TISSUE SPECIFICITY: Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.
    PTM: Autophosphorylated (By similarity).
    SIMILARITY: SwissProt: Q9UQ07 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 200 µL

    merck millipore,默克密理博,AB5484,Anti-RAGE Antibody

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