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merck millipore,默克密理博,MAB2515,Anti-Collagen Type III Antibody, clone 3G4
产品名称：Anti-Collagen Type III Antibody, clone 3G4
产品型号：MAB2515
Anti-Collagen Type III Antibody, clone 3G4 detects level of Collagen Type III & has been published & validated for use in ELISA, IF & IP.
merck millipore,默克密理博,MAB2515,Anti-Collagen Type III Antibody, clone 3G4
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ELISA M Ascites Monoclonal Antibody 描述 产品目录编号 MAB2515 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Collagen Type III Antibody, clone 3G4 产品信息 格式 Ascites 演示 Liquid containing 0.1% sodium azide. 应用 应用 Anti-Collagen Type III Antibody, clone 3G4 detects level of Collagen Type III & has been published & validated for use in ELISA, IF & IP. 主要应用 - ELISA
应用说明 ELISA
Immunofluorescence
Immunoprecipitation生物信息 克隆 3G4 宿主 Mouse 特异性 Monoclonal antibody MAB2515 recognizes human type III collagen. Specifically binds within the triple helical domain of human collagen type III. No cross-reactivity with bovine collagen type III or human collagen types I, II, IV, V, and VII. 同种型 IgM 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000090.3
Entrez基因汇总 This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish] 基因符号 - EDS4A
- COL3A1
- FLJ34534
UniProt编号 - P02461
UniProt汇总 FUNCTION: SwissProt: P02461 # Collagen type III occurs in most soft connective tissues along with type I collagen.
SIZE: 1466 amino acids; 138564 Da
SUBUNIT: Trimers of identical alpha 1(III) chains. The chains are linked to each other by interchain disulfide bonds. Trimers are also cross-linked via hydroxylysines.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
PTM: Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. & O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
DISEASE: SwissProt: P02461 # Defects in COL3A1 are a cause of Ehlers-Danlos syndrome type III (EDS-III) [MIM:130020]; also known as benign hypermobility syndrome. Inheritance is autosomal dominant. EDS is characterized by joint laxity and hyperextensible skin. It is divided into nine different subtypes based on biochemical and clinical variations. & Defects in COL3A1 are the cause of Ehlers-Danlos syndrome type IV (EDS-IV) [MIM:130050]. EDS-IV is the most severe form of the disease, in that it often produces life-threatening consequences, such as rupture of the arteries, bowel, or uterus. A variant form of EDS-IV is Gottron type acrogeria [MIM:201200]. The main characteristics are atrophy and mottled-type hyperpigmentation of the acral skin, resulting in an aged appearance. & Defects in COL3A1 may be a cause of aortic aneurysm [MIM:100070]. Aortic aneurysm consists of a dangerous ballooning of the aorta which is caused by a defect in the artery's wall.
SIMILARITY: SwissProt: P02461 ## Belongs to the fibrillar collagen family. & Contains 1 VWFC domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain frozen at -20°C in undiluted aliquots for up to 12 months after date of receipt. 包装信息 数量 100 µL
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