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merck millipore,默克密理博,MAB5258A4,Anti-Synaptophysin Antibody, clone SY38, Alexa Fluor 488 Conjugate,MAB5258A4
产品名称：Anti-Synaptophysin Antibody, clone SY38, Alexa Fluor 488 Conjugate, MAB5258A4
产品型号：MAB5258A4
merck millipore,默克密理博,MAB5258A4,Anti-Synaptophysin Antibody, clone SY38, Alexa Fluor 488 Conjugate,MAB5258A4
- 产品介绍
- merck millipore,默克密理博,MAB5258A4,Anti-Synaptophysin Antibody, clone SY38, Alexa Fluor 488 Conjugate,MAB5258A4
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H, M IHC M AlexaFluor®488 Monoclonal Antibody 描述 产品目录编号 MAB5258A4 描述 Anti-Synaptophysin Antibody, clone SY38, Alexa Fluor® 488 Conjugate | MAB5258A4 Alternate Names - Major synaptic vesicle protein p38
- Synaptophysin
背景信息 Synaptophysin is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38 kDa. It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. The localization and ubiquitous expression of this protein in neuronal tissue makes it an excellent marker for neurons and neuroendocrine tumors. The gene for this protein is located on the X chromosome (Xp11.23-p11.22). The exact function of the protein is unknown: it interacts with the essential synaptic vesicle protein synaptobrevin, but when the synaptophysin gene is experimentally inactivated in animals, they still develop and function normally. 产品信息 格式 AlexaFluor®488 控制 - Adult mouse brain tissue
演示 Purified mouse monoclonal IgG1κ conjugated to Alexa Fluor® 488 in buffer containing 15 mg/ml BSA with 0.1% sodium azide. 应用 主要应用 - Immunohistochemistry
生物信息 免疫原品种 Vesicular fraction of bovine brain 克隆 SY38 宿主 Mouse 特异性 This antibody reacts with presynaptic vesicles of cerebral and spinal neurons, of neuromuscular endplates and with the retina of man, cow, rat and mouse. It also reacts with vesicles of adrenal medulla and islet cells. 同种型 IgG1 品种反应性 HumanMouse Species Reactivity Note Demonstrated to react with Mouse. Predicted to react with Bovine based on immunogen design. Uncongugated antibody (MAB5258) is shown to work on Rat. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_776388
Entrez基因汇总 Synaptophysin (p38) is an integral membrane protein of small synaptic vesicles in brain and endocrine cells.[supplied by OMIM] 基因符号 - SYP
纯化方法 Protein A purified UniProt编号 - P20488
UniProt汇总 FUNCTION: Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane.
SIZE: 313 amino acids; 33845 Da
SUBUNIT: Homohexamer or homotetramer.
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.
DOMAIN: The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
PTM: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation (By similarity).
SIMILARITY: Belongs to the synaptophysin/synaptobrevin family. & Contains 1 MARVEL domain.产品使用声明 质量保证 Evaluated by Immunohistochemistry in adult mouse brain tissue.
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Synaptophysin in adult mouse brain tissue.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 µL
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