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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M, Mk WB Rb Serum Polyclonal Antibody 描述 产品目录编号 06-195 品牌系列 Upstate
商名 - Upstate
描述 Anti-PI3 Kinase Antibody, p85 背景信息 PI3 Kinase (Phosphatidylinositol 3-Kinase) is responsible for phosphorylation of the 3 position of the inositol ring of PI(4,5)P2, to generate PI(3,4,5)P3, a potent second messenger required for survival signaling, and insulin action. PI3 Kinase is a heterodimeric complex composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. Tyrosine phosphorylation of growth factor receptors creates docking sites for binding of p85 (through its SH2 domains) on the receptors; p85 brings with it p110, which is then proximal to its phospho-lipid substrate on the membrane. PI3 Kinase is also activated by Ras, and by the β,γ subunits of heterotrimeric G-proteins. PI3 Kinase is inhibitable by wortmannin, a useful tool for the study of the PI3 Kinase signaling pathway. 产品信息 格式 Serum 控制 - Positive Control Included: Jurkat cell lysate (12-303)
演示 Immunoaffinity Purified immunoglobulin in 0.2M Tris, 150mM NaCl, 45mM glycine, 0.05% sodium azide and 5mg/ml BSA before the addition of glycerol to 30% 应用 应用 Detect PI3 Kinase using this Anti-PI3 Kinase Antibody, p85 validated for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Glutathione-S-Transferase fusion proteins containing 1) the N-terminal SH2 domain of rat PI3 kinase and 2) the full length 85kDa subunit of rat PI3 kinase 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes p85 subunit of PI3 kinase. 同种型 IgG 品种反应性 RatHumanMouseMonkey 抗体类型 Polyclonal Antibody 基因符号 - p85-ALPHA
- PIK3R1
- GRB1
- PI3K
纯化方法 Unpurified UniProt编号 - Q63787
产品使用声明 质量保证 routinely evaluated by immunoblot on human Jurkat T cells, lysates from mouse NIH 3T3 fibroblasts, rat L6 myoblasts or EGF-stimulated human A431 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 125 µL
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下一件merck millipore产品：merck millipore,默克密理博,MABC743,Anti-Cytochrome C, clone EPR1327, Rabbit Monoclonal Antibody
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