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merck millipore,默克密理博,IL038,Interleukin-1β Protein, Recombinant human
产品名称：Interleukin-1β Protein, Recombinant human
产品型号：IL038
The recombinant human Interleukin-1beta protein (or IL-1beta protein) is a potent immuno-modulator which mediates a wide range of immune & inflammatory responses including the activation of B & T-cell More>>
merck millipore,默克密理博,IL038,Interleukin-1β Protein, Recombinant human
- 产品介绍
重要规格表
主要应用 品种 纯度 CULT Human Greater than 98% by SDS-PAGE and HPLC analysis.Endotoxin level is less than 0..1 ng per μg (1EU//ug) off human IL-1beta.. 描述 产品目录编号 IL038 品牌系列 Chemicon®
商名 - Chemicon
描述 Interleukin-1β Protein, Recombinant human 概述 Interleukin-1beta (IL-1beta) is a potent immuno-modulator which mediates a wide range of immune and inflammatory responses including the activation of B and T-cells. Human IL-1beta is a 17.3 kDa protein containing 153 amino acid residues. Alternate Names - IL-1beta
产品信息 演示 Sterile filtered and lyophilized from 10 mM Tris, pH 8.2 with no preservatives. 应用 应用 The recombinant human Interleukin-1beta protein (or IL-1beta protein) is a potent immuno-modulator which mediates a wide range of immune & inflammatory responses including the activation of B & T-cells. 主要应用 - Cell Culture
应用说明 For most in vitro applications, human IL-1beta is fully biological activity in the concentration range of 0.1 to 10.0 ng/mL. Responding cells are (partial list): Leukocytes. 生物信息 纯度 Greater than 98% by SDS-PAGE and HPLC analysis.Endotoxin level is less than 0..1 ng per μg (1EU//ug) off human IL-1beta.. 品种 Human 特异活性 Chemicon's human IL-1beta is fully biologically active when compared to standards. The ED(50) as determined by the dose-dependent stimulation of the proliferation of murine D10S cells is < 0.001 ng/mL corresponding to a specific activity of > 1 x 10e9 units/mg. Entrez基因编号 - NM_000576.2
Entrez基因汇总 The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. 基因符号 - catabolin
- IL1B
- IL1F2
- pro-interleukin-1-beta
- IL1-BETA
- Catabolin
- IL-1
- IL-1B
UniProt编号 - P01584
UniProt汇总 FUNCTION: SwissProt: P01584 # Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
SIZE: 269 amino acids; 30748 Da
SUBUNIT: Monomer.
SUBCELLULAR LOCATION: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
DOMAIN: SwissProt: P01584 The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
SIMILARITY: Belongs to the IL-1 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 The lyophilized human IL-1beta, though stable at room temperature, is best stored desiccated at -20°C. After a quick spin, reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into other buffered solutions. Reconstituted human IL-1beta should be stored in undiluted aliquots at -20°C for up to six months. 包装信息 数量 10 µg
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