merck millipore,默克密理博,ABC849,Anti-ZIP-1 Antibody

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M, H	IHC, WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	ABC849
描述	Anti-ZIP-1 Antibody
Alternate Names	hZIP1 Zinc transporter ZIP1 Solute carrier family 39 member 1 Zinc-iron-regulated transporter-like Zrt- and Irt-like protein 1 ZIP-1
背景信息	Zinc transporter ZIP1, also known as Solute carrier family 39 member 1 or Zinc-iron-regulated transporter-like or Zrt- and Irt-like protein 1 (ZIP-1 or hZIP1), and encoded by the gene name SLC39A1 or IRT1 or ZIP1 or ZIRTL, is responsible to the rapis uptake and accumulation of physiologically effective zinc in prostate cells. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-κB, leading to downregulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.

产品信息
格式	Affinity Purified
演示	Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

应用
应用	Anti-ZIP-1 Antibody detects level of ZIP-1 & has been published & validated for use in ZIP-1.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected ZIP-1 in human kidney tissue.

生物信息
免疫原品种	KLH-conjugated synthetic peptide corresponding to the N-terminus of human ZIP-1.
表位	N-terminus
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	This antibody is predicted to not cross-react with other ZIP family members.
品种反应性	MouseHuman
抗体类型	Polyclonal Antibody
基因符号	ZIRTL SLC39A1 IRT1 ZIP1
纯化方法	Antigen Affinity purified
UniProt编号	Q9NY26

产品使用声明
质量保证	Evaluated by Western Blotting in Mouse kidney tissue lysate. Western Blotting Analysis: 2 μg/mL of this antibody detected ZIP-1 in Mouse kidney tissue lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,ABC849,Anti-ZIP-1 Antibody

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