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品种反应性 主要应用 宿主 格式 抗体类型 R, M ICC, ELISA, WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB4339 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-REN-1 Antibody, clone 2G6.2 背景信息 REN is a developmentally regulated gene that promotes neural cell differentiation. REN expression is upregulated by embryonic stem cells, following induction by neurogenic signals. It may play a role in neural promotion and can serve as both a marker and regulator of neuronal differentiation. 产品信息 格式 Purified 演示 Liquid in PBS with 0.1% sodium azide 应用 应用 Detect REN-1 using this Anti-REN-1 Antibody, clone 2G6.2 validated for use in ELISA, WB & IC. 主要应用 - Immunocytochemistry
- ELISA
- Western Blotting
生物信息 免疫原品种 Recombinant GST-Murine fusion protein, murine REN-1 克隆 2G6.2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2bκ 品种反应性 RatMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000537.2
Entrez基因汇总 Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. 基因符号 - EC 3.4.23.15
- REN
- Angiotensinogenase
- angiotensinogenase
- renin
- FLJ10761
UniProt编号 - P00797
UniProt汇总 FUNCTION: SwissProt: P00797 # Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
SIZE: 406 amino acids; 45057 Da
SUBUNIT: Interacts with ATP6AP2.
SUBCELLULAR LOCATION: Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2.
DISEASE: SwissProt: P00797 # Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
SIMILARITY: SwissProt: P00797 ## Belongs to the peptidase A1 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. 包装信息 数量 100 µg
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