- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
描述 产品目录编号 14-669 品牌系列 Upstate
商名 - Upstate
描述 DYRK2 Protein, active, 10 µg 概述 6His-tagged, recombinant, full length human DYRK2 应用 应用 Active, 6His-tagged, recombinant, full length human DYRK2, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 expressed by baculovirus in Sf21 cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_006482.1
- NM_003583.2
Entrez基因汇总 DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. 基因符号 - FLJ21217
- DYRK2
- FLJ21365
蛋白靶 DYRK2 纯化方法 Ni2+/NTA-agarose 靶子系列 CMGC UniProt编号 - Q92630
UniProt汇总 FUNCTION: SwissProt: Q92630 # Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.
COFACTOR: Magnesium. & Manganese.
SIZE: 601 amino acids; 66652 Da
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocates into the nucleus following DNA damage.
TISSUE SPECIFICITY: Testis, after the onset of spermatogenesis.
PTM: Phosphorylated on serine/threonine residues (By similarity).
SIMILARITY: SwissProt: Q92630 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of casein 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C 包装信息 数量 10 µg
上一件merck millipore产品：merck millipore,默克密理博,20774,IHC Select Streptavidin-HRP, prediluted
下一件merck millipore产品：merck millipore,默克密理博,04-580,Anti-MALT1/MLT1 (NT) Antibody, clone EP603Y, rabbit monoclonal
merck millipore,默克密理博,612080,TIMP-1, Human Neutrophil Granulocyte - Calbiochem
merck millipore,默克密理博,FCMAB306P,Milli-Mark Anti-Human-Nuclei-PE Antibody, clone 235-1
merck millipore,默克密理博,528100,PI-103 - CAS 371935-74-9 - Calbiochem
merck millipore,默克密理博,70922,BugBuster HT Protein Extraction Reagent
merck millipore,默克密理博,20774,IHC Select Streptavidin-HRP, prediluted
merck millipore,默克密理博,04-580,Anti-MALT1/MLT1 (NT) Antibody, clone EP603Y, rabbit monoclonal
merck millipore,默克密理博,MAB8188,Anti-EBV EA-R-p17 Antibody, clone 5B11
merck millipore,默克密理博,MAB1961F,Anti-Integrin αVβ5 Antibody, clone P1F6, FITC conjugated
merck millipore,默克密理博,MAB3035,Anti-Nucleus and Mitotic Cell Antigen Antibody, clone A73-B/D12
merck millipore,默克密理博,MAB4339,Anti-REN-1 Antibody, clone 2G6.2