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merck millipore,默克密理博,528100,PI-103 - CAS 371935-74-9 - Calbiochem
产品名称：PI-103 - CAS 371935-74-9 - Calbiochem
产品型号：528100
A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR.
merck millipore,默克密理博,528100,PI-103 - CAS 371935-74-9 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₉H₁₆N₄O₃ 371935-74-9 描述 概述 A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR (IC50 = 2, 8, 88, 48, 150, 26, 20, and 83 nM for DNA-PK, p110α, p110β, p110δ, p110γ, PI3-KC2β, mTORC1, and mTORC2, respectively). It inhibits ATR and ATM only at much higher concentrations (IC50 = 850 and 920 nM, respectively) and exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10 µM. Shown to effectively block PI3-K/Akt signaling and cell proliferation in glioma cell lines both in vitro and in vivo. A 10 mM (2 mg/574 µl) solution of PI-103 (Cat. No. 528101) in DMSO is also available. 产品目录编号 528100 品牌系列 Calbiochem®
同义词 3-(4-(4-Morpholinyl)pyrido[3ʹ,2ʹ:4,5]furo[3,2-d]pyrimidin-2-yl)phenol, mTOR Inhibitor V, PI 3-K Inhibitor V 参考 参考 Raynaud, F.I., et al. 2007. Cancer Res. 67, 5840.
Fan, Q.W., et al. 2006. Cancer Cell 9, 341.
Knight, Z.A., et al. 2006. Cell 125, 733.产品信息 CAS号 371935-74-9 具有ATP竞争性 Y 形式 White solid Hill配方 C₁₉H₁₆N₄O₃ 化学配方 C₁₉H₁₆N₄O₃ Molar Mass 348.4 可逆 N 结构配方图像 生物信息 主靶 DNA-PK, PI3-K, and mTOR 主靶IC50 2, 8, 88, 48, 150, 26, 20, and 83 nM for DNA-PK, p110α, p110β, p110delta;, p110γ, PI3-KC2β, mTORC1, and mTORC2, respectively 纯度 ≥97% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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