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merck millipore,默克密理博,04-580,Anti-MALT1/MLT1 (NT) Antibody, clone EP603Y, rabbit monoclonal
产品名称：Anti-MALT1/MLT1 (NT) Antibody, clone EP603Y, rabbit monoclonal
产品型号：04-580
Anti-MALT1/MLT1 (N-Term) Antibody, clone EP603Y detects level of MALT1/MLT1 (N-Term) & has been published & validated for use in FC, IP & WB.
merck millipore,默克密理博,04-580,Anti-MALT1/MLT1 (NT) Antibody, clone EP603Y, rabbit monoclonal
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, FC Rb Purified Monoclonal Antibody 描述 产品目录编号 04-580 品牌系列 Upstate
商名 - Upstate
描述 Anti-MALT1/MLT1 (NT) Antibody, clone EP603Y, rabbit monoclonal Alternate Names - Mucosa-associated lymphoid tissue lymphoma translocation protein 1
背景信息 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), also known as MLT1 or paracaspase 1, is a member of the human paracaspase family and an interacting partner of B-cell lymphoma 10 (Bcl-10) (1). In vitro, In vitro, MALT1 synergizes with BCL10 to enhance nuclear factor B activation (2) and to mediate IB kinase (IKK) activation by facilitating the ubiquitinylation of the NF-B essential modulator (NEMO) (3). MALT1 is found in recurrent chromosomal translocations in non-Hodgkin B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT). One common translocation juxtaposes the MALT1 gene to the IgH promoter region, resulting in up-regulation of Bcl-10 and MALT1 (4). Another common translocation creates a fusion between MALT1 and the inhibitor of apoptosis gene API2 ( cIAP2/HIAP1) (5). 产品信息 格式 Purified 演示 Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. 应用 应用 Anti-MALT1/MLT1 (N-Term) Antibody, clone EP603Y detects level of MALT1/MLT1 (N-Term) & has been published & validated for use in FC, IP & WB. 主要应用 - Western Blotting
- Flow Cytometry
应用说明 WB: 1:2,000
Flow Cytometry: 1:30
IP: 1:50生物信息 免疫原品种 A synthetic peptide corresponding to residues in the N-term of human MALT1. This antibody is predicted to detect splice isoform 2 based on sequence analysis. 克隆 EP603Y 宿主 Rabbit 特异性 Recognizes Human MALT1/MLT1 (N-Term). 品种反应性 Human Species Reactivity Note Human (positive control: Jurkat cell lysate) 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_173844.1
- NM_006785.2
Entrez基因汇总 This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. 基因符号 - DKFZp434L132
- MALT1
- paracaspase
- MLT1
- MLT
- Paracaspase
UniProt编号 - Q9UDY8
UniProt汇总 FUNCTION: SwissProt: Q9UDY8 # Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity.
SIZE: 824 amino acids; 92272 Da
SUBUNIT: Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6.
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Nucleus. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.
TISSUE SPECIFICITY: Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.
DISEASE: SwissProt: Q9UDY8 # A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
SIMILARITY: SwissProt: Q9UDY8 ## Belongs to the peptidase C14 family. & Contains 1 death domain. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at -20 °C. Stable for 12 months from date of receipt. 包装信息 数量 100 µL
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