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merck millipore,默克密理博,AB5964,Anti-Choline Acetyltransferase Antibody
产品名称：Anti-Choline Acetyltransferase Antibody
产品型号：AB5964
Detect Choline Acetyltransferase using this Anti-Choline Acetyltransferase Antibody validated for use in IH & WB.
merck millipore,默克密理博,AB5964,Anti-Choline Acetyltransferase Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5964 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Choline Acetyltransferase Antibody Alternate Names - ChAT
产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Liquid. 应用 应用 Detect Choline Acetyltransferase using this Anti-Choline Acetyltransferase Antibody validated for use in IH & WB. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Immunoblotting
Immunohistochemistry: 1:200 using DAB with nickel enhancement. The antibody has been used successfully on 50μm human medulla sections which were blocked with 3% H2O2 for 30 min, blocked with 10% normal serum (donkey) for 30 min and citrate buffer (pH 3.0) retrieval for 30 min.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Fusion protein 宿主 Rabbit 特异性 Choline Acetyltransferase, human. Does not appear to work on rat or mouse. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_020986.2
- NM_020549.3
- NM_020984.2
- NM_020985.2
Entrez基因汇总 Cholinergic systems are implicated in numerous neurologic functions. Alteration in some cholinergic neurons may account for the disturbances of Alzheimer disease. The protein encoded by this gene synthesizes the neurotransmitter acetylcholine. Alternative splice variants have been found that contain alternative 5' untranslated exons. Three of the four described splice variants encode identical 69 kDa proteins while one variant encodes both the 69 kDa and a larger 82 kDa protein. 基因符号 - EC 2.3.1.6
- CHAT
- ChAT
- CMS1A2
- CHOACTase
- CMS1A
UniProt编号 - P28329
UniProt汇总 FUNCTION: SwissProt: P28329 # Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
SIZE: 748 amino acids; 82568 Da
DISEASE: SwissProt: P28329 # Defects in CHAT are the cause of familial infantile myasthenia gravis 2 (FIMG2) [MIM:254210, 254200]; also known as CMS-EA. FIMG2 patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. Inheritance is autosomal recessive.
SIMILARITY: SwissProt: P28329 ## Belongs to the carnitine/choline acetyltransferase family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.包装信息 数量 100 µg
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