merck millipore,默克密理愽
  • merck millipore,默克密理博,14-553,EphB2 Protein, active, 10 µg

  • merck millipore,默克密理博,14-553,EphB2 Protein, active, 10 µg

    产品名称：EphB2 Protein, active, 10 µg
    产品型号：14-553
    Active, N-terminal His6-tagged recombinant human EphB2 residues 560-end, for use in Kinase Assays.

    merck millipore,默克密理博,14-553,EphB2 Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-553,EphB2 Protein, active, 10 µg

    描述
    产品目录编号 14-553
    品牌系列 Upstate
    商名
    • Upstate
    描述 EphB2 Protein, active, 10 µg
    概述 N-terminal His6-tagged recombinant human EphB2 residues 560-end
    应用
    应用 Active, N-terminal His6-tagged recombinant human EphB2 residues 560-end, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Human EphB2 expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_017449.3
    • NM_004442.6
    Entrez基因汇总 Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.
    基因符号
    • Tyro5
    • EPHB2
    • EphB2
    • CAPB
    • EPHT3
    • Hek5
    • DRT
    • EPTH3
    • TYRO5
    • ERK
    • HEK5
    • MGC87492
    • PCBC
    蛋白靶 EphB2
    纯化方法 Ni2+/NTA-agarose
    靶子系列 TK
    UniProt编号
    • P29323
    UniProt汇总 FUNCTION: SwissProt: P29323 # Receptor for members of the ephrin-B family. Acts as a tumor suppressor.
    SIZE: 1055 amino acids; 117493 Da
    SUBUNIT: The ligand-activated form interacts with multiple proteins, including GTPase-activating protein (RASGAP) through its SH2 domain. Binds RASGAP through the juxtamembrane tyrosines residues. Interacts with PRKCABP and GRIP1 (By similarity).
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.
    DISEASE:SwissProt: P29323 # Defects in EPHB2 are involved in the progression of prostate cancer [MIM:176807]. & Defects in EPHB2 are involved in the development of prostate cancer metastasis to the brain [MIM:603688].
    SIMILARITY: SwissProt: P29323 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. & Contains 2 fibronectin type-III domains. & Contains 1 protein kinase domain. & Contains 1 SAM (sterile alpha motif) domain.
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1)
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 10 µg
    包装 Also available in 250 µg size --call for pricing and availability and reference catalog number 14-553M when ordering the 250 µg size.

    merck millipore,默克密理博,14-553,EphB2 Protein, active, 10 µg

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