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merck millipore,默克密理博,MAB4313X,Anti-CD93 Antibody, clone R3, Alexa Fluor 488 conjugated
产品名称：Anti-CD93 Antibody, clone R3, Alexa Fluor 488 conjugated
产品型号：MAB4313X
Anti-CD93 Antibody, clone R3, Alexa Fluor 488 conjugated detects level of CD93 & has been published & validated for use in FC.
merck millipore,默克密理博,MAB4313X,Anti-CD93 Antibody, clone R3, Alexa Fluor 488 conjugated
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H FC M AlexaFluor®488 Monoclonal Antibody 描述 产品目录编号 MAB4313X 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-CD93 Antibody, clone R3, Alexa Fluor® 488 conjugated Alternate Names - Complement C1q Receptor
背景信息 CD93 (C1qRp) is a 90-120kD protein that is highly expressed on monocytes/macrophages, neutrophils and granulocytes. CD93 is not expressed upon T and B lymphocytes. C1qRp binds C1q, the recognition subunit of the first component (C1) of the complement pathway, as well as MBL (Mannose-binding-lectin) and SPA (Pulmonary Surfactant Protein A). However, CD93 is not necessary for the binding of C1q or for inducing C1q-mediated enhancement of phagocytic activity. Recent evidence suggests that CD93 may define a new human stem cell population with hematopoietic and hepatic potential 3. 产品信息 格式 AlexaFluor®488 控制 - Recommended controls: Positive: U937 monocytes; Negative: T cells
演示 Purified immunoglobulin conjugated to Alexa Fluor® 488. Liquid in Phosphate buffer with 15 mg/mL BSA as a stabilizer and 0.1% sodium azide 应用 应用 Anti-CD93 Antibody, clone R3, Alexa Fluor 488 conjugated detects level of CD93 & has been published & validated for use in FC. 主要应用 - Flow Cytometry
应用说明 Immunocytochemistry: 5-10 μg/ml. Fixative: 4% Paraformaldehyde / PBS. Blocking buffer: 2% BSA / 2% Normal serum / PBS. Dilution Buffer: 2% BSA / 2% Normal serum / PBS. Incubation Times/Temperature: 1 hour at room temperature
FACS Analysis: Suggested dilution/number of cells: 2 μg/million cells. Fixation/Permeabilization used: 1% Paraformaldehyde
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 C1q tail binding proteins 克隆 R3 宿主 Mouse 特异性 Recognizes human CD93 (C1qRp). 同种型 IgM 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_012072.3
Entrez基因汇总 The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. 基因符号 - C1qRP
- CD93
- MXRA4
- C1qRp
- C1qR(P)
- C1qR
- dJ737E23.1
- C1QR1
- CDw93
- p
UniProt编号 - Q9NPY3
UniProt汇总 FUNCTION: SwissProt: Q9NPY3 # Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.
SIZE: 652 amino acids; 68560 Da
SUBUNIT: Interacts with HCV core protein.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.
PTM: N- and O-glycosylated.
SIMILARITY: SwissProt: Q9NPY3 ## Contains 1 C-type lectin domain. & Contains 5 EGF-like domains.产品使用声明 使用声明 - Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
- Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months from date of receipt. Protect from light. 包装信息 数量 100 µg
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