merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1636,Anti-Cytokeratin 4, 5, 6, 8, 10, 13, 18 Antibody, clone C-11

  • merck millipore,默克密理博,MAB1636,Anti-Cytokeratin 4, 5, 6, 8, 10, 13, 18 Antibody, clone C-11

    产品名称：Anti-Cytokeratin 4, 5, 6, 8, 10, 13, 18 Antibody, clone C-11
    产品型号：MAB1636
    This Anti-Cytokeratin 4, 5, 6, 8, 10, 13, 18 Antibody, clone C-11 is validated for use in WB, IC, IH(P) for the detection of Cytokeratin 4.

    merck millipore,默克密理博,MAB1636,Anti-Cytokeratin 4, 5, 6, 8, 10, 13, 18 Antibody, clone C-11

  • 产品介绍
  • merck millipore,默克密理博,MAB1636,Anti-Cytokeratin 4, 5, 6, 8, 10, 13, 18 Antibody, clone C-11

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    VrtICC, WBMAscitesMonoclonal Antibody
    描述
    产品目录编号 MAB1636
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Cytokeratin 4, 5, 6, 8, 10, 13, 18 Antibody, clone C-11
    产品信息
    格式 Ascites
    演示 Ascites fluid.
    应用
    应用 This Anti-Cytokeratin 4, 5, 6, 8, 10, 13, 18 Antibody, clone C-11 is validated for use in WB, IC, IH(P) for the detection of Cytokeratin 4.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry on cultured cells (methanol/acetone fixed).

    Immunohistochemistry on frozen tissue. Suitable for use on paraffin embedded tissue (protease digestion may be necessary).

    Western blot.

    Optimal working dilutions must be determined by end user.
    生物信息
    克隆 C-11
    宿主 Mouse
    特异性 Human keratins 4, 5, 6, 8, 10, 13, 18.Reacts with intermediate filaments of many species up to Xenopus laevis.
    同种型 IgG1
    品种反应性 Vertebrates
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002272.2
    Entrez基因汇总 The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
    基因符号
    • FLJ31692
    • KRT4
    • Cytokeratin-4
    • Keratin-4
    • CK-4
    • CK4
    • CYK4
    • K4
    UniProt编号
    • P05783
    • P19013
    • P13647
    • P02538
    • P05787
    • P13645
    • P13646
    UniProt汇总 FUNCTION: SwissProt: P05787 # Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
    SIZE: 483 amino acids; 53704 Da
    SUBUNIT: Heterotetramer of two type I and two type II keratins. keratin-8 associates with keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP.
    SUBCELLULAR LOCATION: Cytoplasm.
    TISSUE SPECIFICITY: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
    PTM: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
    DISEASE:SwissProt: P05787 # Defects in KRT8 are a cause of cryptogenic cirrhosis [MIM:215600].
    SIMILARITY: SwissProt: P05787 ## Belongs to the intermediate filament family.
    MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at -20ºC in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB1636,Anti-Cytokeratin 4, 5, 6, 8, 10, 13, 18 Antibody, clone C-11

上一件merck millipore产品：merck millipore,默克密理博,HTS109RTA,Ready-to-Assay™ 5-HT2B Serotonin Receptor Frozen Cells
下一件merck millipore产品：merck millipore,默克密理博,ABE623,Anti-TARBP2 Antibody


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