merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB4306,Anti-Human Leukemia Inhibitory Factor Antibody, clone 4F7.2

  • merck millipore,默克密理博,MAB4306,Anti-Human Leukemia Inhibitory Factor Antibody, clone 4F7.2

    产品名称：Anti-Human Leukemia Inhibitory Factor Antibody, clone 4F7.2
    产品型号：MAB4306
    Detect Human Leukemia Inhibitory Factor using this Anti-Human Leukemia Inhibitory Factor Antibody, clone 4F7.2 validated for use in ELISA & WB.

    merck millipore,默克密理博,MAB4306,Anti-Human Leukemia Inhibitory Factor Antibody, clone 4F7.2

  • 产品介绍
  • merck millipore,默克密理博,MAB4306,Anti-Human Leukemia Inhibitory Factor Antibody, clone 4F7.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWB, ELISAMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB4306
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Human Leukemia Inhibitory Factor Antibody, clone 4F7.2
    Alternate Names
    • hLIF
    背景信息 Leukemia inhibitory factor, or LIF, is a pleiotropic cytokine that is expressed by a wide variety of cells including activated T lymphocytes, monocytes, mast cells and neuronal cells. Human LIF cDNA encodes a 202 amino acid precursor which is processed to yield a 180 amino acid, biologically active glycoprotein with an approximate molecular weight of 38-67 kDa. In addition to its involvement in the stimulation of acute-phase protein during inflammatory processes, LIF has also been implicated in promoting the survival and growth of axons in vitro. LIF signals through the LIF receptor, a heterodimer comprised of a 190 kDa LIFR subunit and the gp130 subunit common to the IL-6, IL-11, CNTF and OSM receptors. Janus tyrosine kinases, JAK1 and JAK2, are activated in response to LIF stimulation, which in turn phosphorylate Stat1 and Stat3 causing their nuclear translocation and the transcription of Stat-responsive genes.
    产品信息
    格式 Purified
    控制
    • Jurkat whole cell lysate
    应用
    应用 Detect Human Leukemia Inhibitory Factor using this Anti-Human Leukemia Inhibitory Factor Antibody, clone 4F7.2 validated for use in ELISA & WB.
    主要应用
    • Western Blotting
    • ELISA
    生物信息
    克隆 4F7.2
    宿主 Mouse
    同种型 IgG1
    品种反应性 MouseHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002309.2
    Entrez基因汇总 Leukaemia inhibitory factor is a cytokine that induces macrophage differentiation. Neurotransmitters and neuropeptides, well known for their role in the communication between neurons, are also capable of activating monocytes and macrophages and inducing chemotaxis in immune cells. LIF signals through different receptors and transcription factors. LIF in conjunction with BMP2 acts in synergy on primary fetal neural progenitor cells to induce astrocytes.
    基因符号
    • D-FACTOR
    • LIF
    • Emfilermin
    • CDF
    • MLPLI
    • HILDA
    UniProt编号
    • P15018
    UniProt汇总 FUNCTION: SwissProt: P15018 # LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
    SIZE: 202 amino acids; 22008 Da
    SUBCELLULAR LOCATION: Secreted.
    SIMILARITY: SwissProt: P15018 ## Belongs to the LIF/OSM family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB4306,Anti-Human Leukemia Inhibitory Factor Antibody, clone 4F7.2

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