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merck millipore,默克密理博,MAB4162,Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17
产品名称：Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17
产品型号：MAB4162
Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17 is an antibody against MDR1 for use in FC, IH.
merck millipore,默克密理博,MAB4162,Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, FC M Purified Monoclonal Antibody 描述 产品目录编号 MAB4162 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17 Alternate Names - Pgp
- P-glycoprotein
- CD243
- p170
产品信息 格式 Purified 控制 - MDR cells
演示 Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative. 应用 应用 Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17 is an antibody against MDR1 for use in FC, IH. 主要应用 - Immunohistochemistry
- Flow Cytometry
应用说明 Flow Cytometry
Immunohistochemistry on formalin fixed paraffin embedded sections
Confocal and Electron Microscopy
ELISA
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Living intact human multidrug-resistant cells 表位 extracellular human specific Pgp 克隆 MM4.17 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Recognizes a mapped epitope in the extracellular Pgp domain and detects low-level Pgp expression in living (intact) human MDR cells (Cianfriglia, 2002). The epitope has been mapped to the single amino acid level using different techniques (Cianfriglia, 1994 and Poloni, 1995). 同种型 IgG2aκ 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000927.3
Entrez基因汇总 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. 基因符号 - EC 3.6.3.44
- ABCB1
- PGY1
- MGC163296
- GP170
- ABC20
- CD243
- P-gp
- MDR1
- CLCS
纯化方法 Protein A purfied UniProt编号 - P08183
UniProt汇总 FUNCTION: SwissProt: P08183 # Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
SIZE: 1280 amino acids; 141463 Da
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in liver, kidney, small intestine and brain.
SIMILARITY: SwissProt: P08183 ## Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. & Contains 2 ABC transmembrane type-1 domains. & Contains 2 ABC transporter domains.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 100 µg
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