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merck millipore,默克密理博,S7700,TRAPeze Telomerase Detection Kit
产品名称：TRAPeze Telomerase Detection Kit
产品型号：S7700
A highly sensitive in vitro PCR based assay for detecting telomerase activity based on the TRAP assay (Telomeric Repeat Amplification Protocol).
merck millipore,默克密理博,S7700,TRAPeze Telomerase Detection Kit
- 产品介绍
重要规格表
品种反应性 主要应用 检测方法 Ma RT-PCR Chromogenic 描述 产品目录编号 S7700 品牌系列 Chemicon®
商名 - Chemicon
- TRAPeze
描述 TRAPeze® Telomerase Detection Kit 概述 The TRAPeze® Telomerase Detection Kit is a highly sensitive in vitro assay system for detecting telomerase activity. The assay is a one-buffer, two-enzyme, system utilizing PCR to enhance the sensitivity of telomerase detection in small samples.
Recommended Taq polymerases: must be non-proofreading, having no exonuclease activity and capable of "hot-start." Titanium Taq™, Platinum® Taq are suggested.Alternate Names - TRAP Assay
背景信息 Telomeres are specific structures found at the ends of chromosomes in
eukaryotes. In human chromosomes, telomeres consist of thousands of copies of 6 base repeats (TTAGGG). It has been suggested that telomeres protect chromosome ends, because damaged chromosomes lacking telomeres undergo fusion, rearrangement and translocation. In somatic cells, telomere length is progressively shortened with each cell division both in vivo and in vitro, due to the inability of the DNA polymerase complex to replicate the very 5' endof the lagging strand .
Telomerase is a ribonucleoprotein that synthesizes and directs the telomeric
repeats onto the 3' end of existing telomeres using its RNA component as a
template. Telomerase activity has been shown to be specifically expressed in immortal cells, cancer and germ cells, where it compensates for telomere shortening during DNA replication and thus stabilizes telomere length. These observations have led to a hypothesis that telomere length may function as a “mitotic clock” to sense cell aging and eventually signal replicative senescence or programmed cell death. Therefore, expression of telomerase activity in cancer cells may be a necessary and essential step for tumor development and progression. The causal relationship between expression of telomerase and telomere length stabilization and the extension of the life span of the human cell has recently been reported.产品信息 检测方法 Chromogenic 应用 应用 A highly sensitive in vitro PCR based assay for detecting telomerase activity based on the TRAP assay (Telomeric Repeat Amplification Protocol). 主要应用 - PCR
生物信息 品种反应性 Mammals 产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
包装信息 数量 112 assays
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