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  • merck millipore,默克密理博,07-428-I,Anti-phospho eNOS Antibody (Ser1177)

  • merck millipore,默克密理博,07-428-I,Anti-phospho eNOS Antibody (Ser1177)

    产品名称：Anti-phospho eNOS Antibody (Ser1177)
    产品型号：07-428-I
    Anti-phospho eNOS Antibody (Ser1177) is a highly specific rabbit polyclonal antibody, that targets eNOS/NOS III & has been tested in western blotting.

    merck millipore,默克密理博,07-428-I,Anti-phospho eNOS Antibody (Ser1177)

  • 产品介绍
  • merck millipore,默克密理博,07-428-I,Anti-phospho eNOS Antibody (Ser1177)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-428-I
    Replaces 07-428
    描述 Anti-phospho eNOS Antibody (Ser1177)
    Alternate Names
    • NOSIII
    • Nitric oxide synthase, endothelial
    • Constitutive NOS
    • cNOS
    • EC-NOS
    • Endothelial NOS
    • eNOS
    • NOS type III
    背景信息 NO, produced by nitric oxide synthases (NOS), is a critical signaling molecule involved in many physiological processes including muscle contraction, vasodilation, neuronal transmission, and immune responses. Some of these effects are mediated through reaction with and activation of guanylate cyclase (GC), resulting in increased cGMP production. With a half-life of seconds, NO readily diffuses through the cytosol and cell membrane, allowing it to act inside or adjacent to the cell in which it was produced. Nitric oxide (NO) is an inorganic, gaseous free radical that carries a variety of messages between cells. Vasorelaxation, neurotransmission and cytotoxicity can all be potentiated through cellular response to NO. NO production is mediated by members of the nitric oxide synthase (NOS) family. NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms, brain or neuronal NOS (b or nNOS, type I) & endothelial cell NOS (eNOS, type III), and one inducible isoform (iNOS, type II), have been cloned. Cytokines such as interferon-gamma (IFN), tumor necrosis factor (TNF), interleukin-1 and -2, and lipopolysaccarides (LPS) cause an increase in iNOS mRNA, protein, and activity levels. Protein kinase C-stimulating agents exhibit the same effect on iNOS activity. Human iNOS is regulated by calcium/calmodulin (in contrast with mouse NOS2).
    产品信息
    格式 Affinity Purified
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-phospho eNOS Antibody (Ser1177) is a highly specific rabbit polyclonal antibody, that targets eNOS/NOS III & has been tested in western blotting.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to a region near the C-terminus of human eNOS phosphorylated at Ser1177.
    表位 Near C-terminus
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human. Predicted to react with Mouse, Rat, Bovine, Canine, Sheep, and Porcine based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_000594
    基因符号
    • NOS3
    修改
    • Phosphorylation
    纯化方法 Affinity purified
    UniProt编号
    • P29474
    产品使用声明
    质量保证 Evaluated by Western Blotting in untreated and VEGF treated HUVEC cell lysate.

    Western Blotting Analysis: 2 µg/mL of this antibody detected phospho eNOS (Ser1177) in 10 µg of VEGF treated HUVEC cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 200 µL

    merck millipore,默克密理博,07-428-I,Anti-phospho eNOS Antibody (Ser1177)

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