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  • merck millipore,默克密理博,ABE551,Anti-E3 ubiquitin-protein ligase UHRF1 Antibody

  • merck millipore,默克密理博,ABE551,Anti-E3 ubiquitin-protein ligase UHRF1 Antibody

    产品名称：Anti-E3 ubiquitin-protein ligase UHRF1 Antibody
    产品型号：ABE551
    Detect UHRF1 using this rabbit polyclonal antibody, Anti-E3 ubiquitin-protein ligase UHRF1 Antibody validated for use in western blotting & IHC.

    merck millipore,默克密理博,ABE551,Anti-E3 ubiquitin-protein ligase UHRF1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABE551,Anti-E3 ubiquitin-protein ligase UHRF1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABE551
    描述 Anti-E3 ubiquitin-protein ligase UHRF1 Antibody
    Alternate Names
    • Ubiquitin-like-containing PHD and RING finger domains protein 1
    • E3 ubiquitin-protein ligase UHRF1
    • Inverted CCAAT box-binding protein of 90 kDa
    • Nuclear protein 95
    • Nuclear zinc finger protein Np95
    • HuNp95
    • hNp95
    • RING finger protein 106
    • Transcription factor ICBP90
    • Ubiquitin-like PHD and RING finger domain-containing protein 1
    • hUHRF1
    背景信息 Ubiquitin-like with PHD and ring finger domains 1 (UHRF1), also known as ICBP90 or Np95, is a multifunctional nuclear protein that may be an important mediator of heterochromatin formation which is indicative of gene repression. UHRF1 contains a set and RING-finger-associated domain that detects hemi-methylated cytosine residues leading to the recruitment of DNMT1 to these residues during the S phase. UHRF1 thereby facilitates the transfer of methylation status to newly synthesized DNA molecules. UHRF1 may also interact with histones and HDAC1 via its PHD domain to promote modifications of histone residues which contribute to heterochromatin formation. UHRF1 may also directly modify histone H3 by ubiquitination. In addition, UHRF1 may contribute to the DNA-repair process though associations with PCNA. Several studies have suggested that overexpression of UHRF1 may contribute to the development of many cancers.
    产品信息
    格式 Affinity Purified
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect UHRF1 using this rabbit polyclonal antibody, Anti-E3 ubiquitin-protein ligase UHRF1 Antibody validated for use in western blotting & IHC.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected E3 ubiquitin-protein ligase UHRF1 in human breast cancer tissue.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to a region near the C-terminus of human E3 ubiquitin-protein ligase UHRF1.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human. Predicted to react with Primate, Feline, Bovine, Porcine, Horse, and Canine based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号

    • ">NP_001041666.1
    基因符号
    • RNF106
    • UHRF1
    • NP95
    纯化方法 Affinity purified
    UniProt编号
    • Q96T88
    产品使用声明
    质量保证 Evaluated by Western Blotting in HEK293 cell lysate.

    Western Blotting Analysis: 0.5 µg/mL of this antibody detected E3 ubiquitin-protein ligase UHRF1 in 10 µg of HEK293 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABE551,Anti-E3 ubiquitin-protein ligase UHRF1 Antibody

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