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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB, ICC M Culture Supernatant Monoclonal Antibody 描述 产品目录编号 MAB4148 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-MRP2 Antibody, clone M2 I-4 Alternate Names - cMOAT
产品信息 格式 Culture Supernatant 演示 Liquid containing 0.7% BSA and 0.1% sodium azide. 应用 应用 This Anti-MRP2 Antibody, clone M2 I-4 is validated for use in WB, IC, IH for the detection of MRP2. 主要应用 - Immunohistochemistry
- Western Blotting
- Immunocytochemistry
应用说明 Western blotting: 1:20 - 1:50 with anti-mouse HRP
Immunocytochemistry: 1:20 - 1:50 on acetone fixed cytospin preparations
Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Fusion protein of MRP2 containing aa 215-310 of the protein. 克隆 M2 I-4 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody reacts with an internal epitope of MRP2, a 190-200 kDa transmembrane protein previously known as the canalicular multi-organic anion transporter (cMOAT). MRP2 is a member of the MRP family of multidrug resistance related proteins, and MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines. This antibody does not cross-react with the human MDR1, MRP1, MRP3 or MRP5 gene products. 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000392.2
Entrez基因汇总 The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. 基因符号 - cMRP
- ABCC2
- MRP2
- ABC#
- CMOAT1
- CMOAT
- ABC30
- CMRP
- DJS
- KIAA1010
UniProt编号 - Q92887
UniProt汇总 FUNCTION: SwissProt: Q92887 # Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
SIZE: 1545 amino acids; 174191 Da
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.
DISEASE: SwissProt: Q92887 # Defects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.
SIMILARITY: SwissProt: Q92887 ## Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily. & Contains 2 ABC transmembrane type-1 domains. & Contains 2 ABC transporter domains.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C for up to 6 months. For long-term storage store at -20°C. 包装信息 数量 100 µg
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