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merck millipore,默克密理博,MAB4073,Anti-CD44v6 Antibody, exon v6, clone VFF-18
产品名称：Anti-CD44v6 Antibody, exon v6, clone VFF-18
产品型号：MAB4073
This Anti-CD44v6 Antibody, exon v6, clone VFF-18 is validated for use in FC, WB, IC, IH(P) for the detection of CD44v6.
merck millipore,默克密理博,MAB4073,Anti-CD44v6 Antibody, exon v6, clone VFF-18
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ICC, FC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB4073 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-CD44v6 Antibody, exon v6, clone VFF-18 产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in PBS with no preservative. 应用 应用 This Anti-CD44v6 Antibody, exon v6, clone VFF-18 is validated for use in FC, WB, IC, IH(P) for the detection of CD44v6. 主要应用 - Immunocytochemistry
- Flow Cytometry
- Western Blotting
应用说明 Immunohistochemistry on acetone fixed cryostat sections using the alkaline phosphatase-anti-alkaline-phosphatase (APAAP) or peroxidase anti-peroxidase (PAP) procedures. Antibody may be used at a concentration of 1 - 2 μg/mL.
Immunohistochemistry on paraffin embedded sections after microwave treatment (1 x 5 min). Antibody may be used at a concentration of 1 - 2 μg/mL.
Immunocytochemistry on cell smears.
Western blot
Flow cytometry: 1:20 dilution
Optimal working dilutions must be determined by end user.生物信息 表位 exon v6 克隆 VFF-18 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Specific for an epitope encoded by exon v6 on the variant portion of human CD44. 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_001001392.1
- NM_000610.3
- NM_001001389.1
- NM_001001390.1
- NM_001001391.1
Entrez基因汇总 The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. 基因符号 - HCELL
- CD44
- LHR
- HUTCH-I
- CDW44
- CDw44
- ECMR-III
- Epican
- MGC10468
- CD44R
- PGP-1
- MDU2
- CSPG8
- Pgp1
- IN
- MUTCH-I
- MIC4
- MDU3
- MC56
UniProt编号 - P16070
UniProt汇总 FUNCTION: SwissProt: P16070 # Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
SIZE: 742 amino acids; 81554 Da
SUBUNIT: Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: An epithelial isoform (CD44E) is expressed by cells of epithelium and highly expressed by carcinomas. An hematopoietic isoform (CD44H) is expressed by cells of mesodermal origin. Expression is repressed in neuroblastoma cells.
PTM: Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors. & N-glycosylated. & O-glycosylated; contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). & Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.
SIMILARITY: SwissProt: P16070 ## Contains 1 Link domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain frozen at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µg
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