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品种反应性 主要应用 宿主 格式 抗体类型 Rb, Ca, H, M, R ICC, ELISA, WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB3822 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Ezrin Antibody, clone 4A5 Alternate Names - p81
- Cytovilli
- Villin 2
产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid containing 0.1% sodium azide. 应用 应用 Detect Ezrin using this Anti-Ezrin Antibody, clone 4A5 validated for use in ELISA, WB & IC. 主要应用 - Immunocytochemistry
- ELISA
- Western Blotting
应用说明 Western blot. The antibody recognizes the ~80 kDa Ezrin protein. A breakdown product of ~55 kDa may also be seen depending on sample and concentration used.
Immunocytochemistry. Ezrin is periferal membrane protein localized to the cytoplasmic side of microvilli associated with intestinal epithelial cells. The use of fixatives containing gluteraldehyde is strongly discouraged.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Ezrin was isolated and purified from gastric parietal cells from rabbit. 克隆 4A5 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Reacts with Ezrin. 同种型 IgG1 品种反应性 RabbitCanineHumanMouseRat 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_003379.4
- NM_001111077.1
Entrez基因汇总 The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. 基因符号 - CVIL
- EZR
- Villin-2
- VIL2
- Ezrin
- MGC1584
- CVL
- Cytovillin
- FLJ26216
- p81
- DKFZp762H157
UniProt编号 - P15311
UniProt汇总 FUNCTION: SwissProt: P15311 # Probably involved in connections of major cytoskeletal structures to the plasma membrane.
SIZE: 586 amino acids; 69413 Da
SUBUNIT: Interacts with MPP5 (By similarity). Interacts with SLC9A3R1 and PACE1.
SUBCELLULAR LOCATION: Membrane. Note=Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side).
TISSUE SPECIFICITY: Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied.DEVELOPMENTAL STAGE: Very strong staining is detected in the Purkinje cell layer and in part of the molecular layer of the infant brain compared to adult brain.
PTM: Phosphorylated by tyrosine-protein kinases.
SIMILARITY: SwissProt: P15311 ## Contains 1 FERM domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,474790,MG-132 - CAS 133407-82-6 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,MABS63,Anti-phospho-PLCγ-1 (Tyr783) Antibody, clone 12F4.2
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