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  • merck millipore,默克密理博,MAB363,Anti-NMDAR1 Antibody, clone 54.1

  • merck millipore,默克密理博,MAB363,Anti-NMDAR1 Antibody, clone 54.1

    产品名称：Anti-NMDAR1 Antibody, clone 54.1
    产品型号：MAB363
    Anti-NMDAR1 Antibody, clone 54.1 is an antibody against NMDAR1 for use in ELISA, IC, IH, IH(P), RIA.

    merck millipore,默克密理博,MAB363,Anti-NMDAR1 Antibody, clone 54.1

  • 产品介绍
  • merck millipore,默克密理博,MAB363,Anti-NMDAR1 Antibody, clone 54.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Xn, H, Mk, RIHC, ELISA, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB363
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-NMDAR1 Antibody, clone 54.1
    Alternate Names
    • glutamate receptor, ionotropic, N-methyl D-aspartate 1
    • N-methyl-D-aspartate receptor channel, subunit zeta-1
    • N-methyl-D-aspartate receptor subunit NR1
    • NMDA receptor 1
    • glutamate [NMDA] receptor subunit zeta 1
    • glutamate [NMDA] receptor subunit zeta 1
    • glutamate receptor
    • ionotropic
    背景信息 Glutamate is a widely utilized excitatory neurotransmitter in mammalian brain. The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate (KA) and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are referred to as non-NMDA receptors. Two distinct genes encode the NMDA receptor subunits, NR1 and NR2. The NR1 subunit is expressed in abundance in virtually all regions of the brain.
    产品信息
    格式 Purified
    控制
    • Rat brain and spinal cord tissue
    演示 Purified mouse monoclonal IgG2a liquid in buffer PBS, no preservative.
    应用
    应用 Anti-NMDAR1 Antibody, clone 54.1 is an antibody against NMDAR1 for use in ELISA, IC, IH, IH(P), RIA.
    主要应用
    • Immunohistochemistry
    • ELISA
    • Immunocytochemistry
    应用说明 Immunocytochemistry:
    A previous lot of this antibody was used in IC.

    RIA:
    A previous lot of this antibody was used in RIA.

    ELISA:
    A previous lot of this antibody was used in ELISA.

    Immunohistochemistry: 1:500-2000, on 2-4% paraformaldehyde fixed tissue: typically free-floating, frozen or vibratome sections 24-48 hours at 4°C. Paraffin embedded formalin fixed sections have also been used at similar dilutions and incubation times. Care should be taken not to over fix the tissues. The clone 54.1 has been used for both light and electron microscopy.

    Western blot:
    1:500 with 50 migrograms/lane of material. Recognizes a 103-116kDa band.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Recombinant fusion protein containing GST and NMDAR1 aa. 660-811.
    表位 Extracellular loop between transmembrane regions III & IV.
    克隆 54.1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes an epitope between amino acids 660-811 of the NMDAR1 receptor. Shows no cross-reactivity with NMDAR2, NMDAR3, NMDAR4 or NMDAR5.
    同种型 IgG2a
    品种反应性 XenopusHumanMonkeyRat
    Species Reactivity Note Human, Rat, Monkey and Xenopus.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000832.5
    Entrez基因汇总 The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.
    基因符号
    • NMDA1
    • GRIN1
    • NR1
    • Glutamate
    • NMDAR1
    纯化方法 Protein A purfied
    UniProt编号
    • Q05586
    UniProt汇总 FUNCTION: SwissProt: Q05586 # NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).
    SIZE: 938 amino acids; 105373 Da
    SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ (By similarity).
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Note=Enriched in post-synaptic plasma membrane and post-synaptic densities (By similarity).
    PTM: NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity (By similarity).
    SIMILARITY: SwissProt: Q05586 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
    产品使用声明
    质量保证 Evaluated by immunohistochemistry on rat brain and spinal cord tissue.

    Immunohistochemistry(paraffin) Analysis:
    NMDAR1 representative staining pattern/morphology on rat spinal cord at 1:200 dilution. Immunoreactivity is seen as integral membrane and nerve fiber staining of neurons. Frozen section. IHC -Frozen Staining Examples: Rat Spinal Cord
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20ºC from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB363,Anti-NMDAR1 Antibody, clone 54.1

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