- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, ICC, IHC M Purified Monoclonal Antibody 描述 产品目录编号 05-510 Replaces 04-1159 品牌系列 Upstate
商名 - Upstate
描述 Anti-TCF-1 Antibody, clone 7H3 背景信息 TCF 1 (T cell factor 1) is a member of the TCF/LEF (lymphoid enhancer factor) family of transcription factors. Members of this family along with b catenin, are involved in mediating Wnt signaling by transactivating downstream genes. TCF 1 is closely related to LEF-1, both of which are transcription factors expressed in mice during T cell differentiation. They regulate the T cell receptor a enhancer in transfections assays. TCF 1 becomes transcriptionally active through interaction with b catenin. Also, numerous splice variants of TCF 1 have been identified. Overexpression of TCF-1-specific splice forms appears to correlate with the metastatic behavior of colorectal cancer cells and with overproduction of lymphoid tyrosine protein kinase p56(lck). 产品信息 格式 Purified 控制 - Positive Control Included: Jurkat cell lysate (12-303)
演示 Protein G Purified immunoglobulin in Immunoaffinity Purified immunoglobulin in 0.2M Tris-glycine, pH 7.5, 0.15M NaCl and 0.05% sodium azide 应用 应用 Detect TCF-1 with Anti-TCF-1 Antibody, clone 7H3 (Mouse Monoclonal Antibody), that has been shown to work in ICC, IHC & WB. 主要应用 - Western Blotting
- Immunocytochemistry
- Immunohistochemistry
生物信息 免疫原品种 Maltose binding protein (MBP) fusion protein corresponding to residues 102-269 of human TCF-1A splice variant. The epitope maps to a region just N-terminal to the High Mobility Group (HMG) box 克隆 7H3 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Recognizes multiple splice isoforms of TCF-1. 同种型 IgG 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_003202
基因符号 - HNF1a
- TCF1
- MODY3
- TCF-1
- HNF1
- HNF-1A
- HNF1A
- LFB1
纯化方法 Protein G purfied UniProt编号 - P36402
UniProt汇总 FUNCTION: SwissProt: P20823 # Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
SIZE: 631 amino acids; 67356 Da
SUBUNIT: Binds DNA as a dimer.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Liver.
DISEASE: SwissProt: P20823 # Defects in HNF1A may predispose to hepatic adenomas [MIM:142330]. Hepatic adenomas are benign tumors at risk of malignant transformation. Bi-allelic inactivation of HNF1A, whether sporadic or associated with MODY3, may be an early step in the developmant of some hepatocellular carcinomas. & Defects in HNF1A are the cause of maturity onset diabetes of the young type 3 (MODY3) [MIM:600496]; also symbolized MODY-3. MODY [MIM:606391] is a form of diabetes characterized by an autosomal dominant mode of inheritance, age of onset of 25 years or younger and a primary defect in insulin secretion. The clinical phenotype of MODY3 is characterized by severe insulin secretory defects, and by major hyperglycemia associated with microvascular complications. & Defects in HNF1A are a cause of susceptibility to insulin-dependent diabetes mellitus (IDDM) [MIM:222100].
SIMILARITY: SwissProt: P20823 ## Belongs to the HNF1 homeobox family. & Contains 1 homeobox DNA-binding domain.产品使用声明 质量保证 routinely evaluated by immunoblot on Jurkat RIPA cell lysate 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,344039,cFMS Receptor Inhibitor IV - CAS 959626-45-0 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,480401,NFAT Inhibitor, Cell-Permeable - Calbiochem
相关产品
merck millipore,默克密理博,04-282,Anti-phospho-EGFR (Thr654) Antibody, clone 3F2
merck millipore,默克密理博,64-202BP,Visualizer™ Western Blot Detection Kit, rabbit
merck millipore,默克密理博,14-509,Rsk1/MAPKAP Kinase 1a Protein, active, Human, 10 µg
merck millipore,默克密理博,CC4000,Urokinase-type Plasminogen Activator
merck millipore,默克密理博,344039,cFMS Receptor Inhibitor IV - CAS 959626-45-0 - Calbiochem
merck millipore,默克密理博,480401,NFAT Inhibitor, Cell-Permeable - Calbiochem
merck millipore,默克密理博,MAB363,Anti-NMDAR1 Antibody, clone 54.1
merck millipore,默克密理博,14-520,Casein Kinase 1δ (aa 1-294) Protein, active, 10 µg
merck millipore,默克密理博,MAB318,Anti-Tyrosine Hydroxylase Antibody, clone LNC1
merck millipore,默克密理博,CC1890,Aggrecan Interglobular Domain, Recombinant, His-tagged