merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB318,Anti-Tyrosine Hydroxylase Antibody, clone LNC1

  • merck millipore,默克密理博,MAB318,Anti-Tyrosine Hydroxylase Antibody, clone LNC1

    产品名称：Anti-Tyrosine Hydroxylase Antibody, clone LNC1
    产品型号：MAB318
    Detect Tyrosine Hydroxylase using this Anti-Tyrosine Hydroxylase Antibody, clone LNC1 validated for use in IH, IH(P), IP & WB.

    merck millipore,默克密理博,MAB318,Anti-Tyrosine Hydroxylase Antibody, clone LNC1

  • 产品介绍
  • merck millipore,默克密理博,MAB318,Anti-Tyrosine Hydroxylase Antibody, clone LNC1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Zebrafish, Ch, Fg, H, M, Mk, R, Lz, VoWB, IHCMAscitesMonoclonal Antibody
    描述
    产品目录编号 MAB318
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Tyrosine Hydroxylase Antibody, clone LNC1
    Alternate Names
    • Tyrosine Monooxygenase
    • TH
    背景信息 Tyrosine hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. At least four isoforms of human TH have been identified which result from alternative splicing.
    产品信息
    格式 Ascites
    控制
    • Human brain tissue, extracts from 3T3 cells treated with Forskolin (40 nM, 30 min).
    演示 Ascites mouse monoclonal IgG1κ fluid containing 3% BSA. Contains no preservative.
    应用
    应用 Detect Tyrosine Hydroxylase using this Anti-Tyrosine Hydroxylase Antibody, clone LNC1 validated for use in IH, IH(P), IP & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Immunohistochemistry(paraffin):
    A 1:200-1:400 dilution of a previous lot was used in IH. 4% PFA fixed, frozen sections; 4% PFA fixed, paraffin sections 1:100 (Barrachina, M. et al., 2003). For paraffin sections Barrachina reported successful staining with microwave citrate acid antigen recovery, however other methods can likely be used as well.

    Immunoprecipitation:
    A previous lot of this antibody was used in IP (Perez, 2002).

    Optimal working dilutions and protocols must be determined by end user.
    生物信息
    免疫原品种 Tyrosine Hydroxylase purified from PC12 cells
    克隆 LNC1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes an epitope on the outside of the regulatory N-terminus. Recognizes a protein of approximately 59-61 kDa by Western blot. Does not react with the following on Western Blots: dopamine-beta-hydroxylase, phenylalanine hydroxylase, trytophan hydroxylase, dehydropteridine reductase, sepiapterin reductase or phenethanolamine-N-methyl transferase (PNMT).
    同种型 IgG1κ
    品种反应性 ZebrafishChickenFrogHumanMouseMonkeyRatLizardVole
    Species Reactivity Note Human, mouse, rat, chicken, frog, lizard, monkey, vole and zebrafish.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000360.3
    Entrez基因汇总 Tyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons.
    基因符号
    • EC 1.14.16.2
    • TH
    • TYH
    纯化方法 Unpurified
    UniProt编号
    • P07101
    UniProt汇总 FUNCTION: SwissProt: P07101 # Plays an important role in the physiology of adrenergic neurons.
    COFACTOR: Fe(2+) ion.
    SIZE: 528 amino acids; 58524 Da
    TISSUE SPECIFICITY: Mainly expressed in the brain and adrenal glands.
    DISEASE: SwissProt: P07101 # Defects in TH are the cause of autosomal recessive Segawa syndrome [MIM:605407]; also known as DOPA-responsive dystonia. Typically, it begins in childhood or adolescence with progressive difficulty in walking and, in some cases, spasticity. Some cases present with parkinsonian symptoms in infancy and are referred to as autosomal recessive infantile parkinsonism.
    SIMILARITY: SwissProt: P07101 ## Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
    产品使用声明
    质量保证 Routinely evaluated by Western Blot on Mouse Brain lysates.

    Western blot:
    1:1000 dilution of this lot detected Tyrosine Hydroxylase on 10 μg of Mouse Brain lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20ºC from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB318,Anti-Tyrosine Hydroxylase Antibody, clone LNC1

上一件merck millipore产品：merck millipore,默克密理博,14-520,Casein Kinase 1δ (aa 1-294) Protein, active, 10 µg
下一件merck millipore产品：merck millipore,默克密理博,CC1890,Aggrecan Interglobular Domain, Recombinant, His-tagged


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