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merck millipore,默克密理博,480401,NFAT Inhibitor, Cell-Permeable - Calbiochem
产品名称：NFAT Inhibitor, Cell-Permeable - Calbiochem
产品型号：480401
The NFAT Inhibitor, Cell-Permeable controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
merck millipore,默克密理博,480401,NFAT Inhibitor, Cell-Permeable - Calbiochem
- 产品介绍
重要规格表
经验配方 C₁₄₇H₂₅₉N₆₇O₃₆S 描述 概述 A cell-permeable version of NFAT Inhibitor (Cat. No. 480402) that is modified at the N-terminal with an eleven arginine transduction domain and a three glycine linker sequence. Prevents the activation and proliferation of T cells both in vitro ( ~ 43% at 1 µM using mixed lymphocyte cultures) and in vivo (10 mg/kg using C3H/HeN mice). Shown to be effective in providing immunosuppression in a murine islet xenograft model. Unlike Cyclosporin A (Cat. No. 239835) and FK506, 11R-VIVIT does not cause side effects outside the immune system as a result of calcineurin (Cat. No. 539568) inhibition and therefore serves as a less toxic alternative for in vivo applications. The functional half-life of 11R-VIVIT has been estimated to be ~30 h in Jurkat cells. 产品目录编号 480401 品牌系列 Calbiochem®
同义词 11R-VIVIT, Nuclear Factor of Activated T cells Inhibitor, RRRRRRRRRRR-GGG-MAGPHPVIVITGPHEE 参考 参考 Noguchi, H., et al. 2004. Nat. Med. 10, 305. 产品信息 具有ATP竞争性 N 形式 Lyophilized white solid 配方 Supplied as a trifluoroacetate salt. Hill配方 C₁₄₇H₂₅₉N₆₇O₃₆S 化学配方 C₁₄₇H₂₅₉N₆₇O₃₆S Molar Mass 3573.1 吸湿 Hygroscopic
肽序列 H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH 可逆 N 生物信息 主靶 NFAT 主靶IC50 Use at 1 µM for preventing the activation and proliferation of T cells 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or H₂O 肽序列 H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Harmful
储存 -20°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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