merck millipore,默克密理愽
  • merck millipore,默克密理博,CC4000,Urokinase-type Plasminogen Activator

  • merck millipore,默克密理博,CC4000,Urokinase-type Plasminogen Activator

    产品名称：Urokinase-type Plasminogen Activator
    产品型号：CC4000


    merck millipore,默克密理博,CC4000,Urokinase-type Plasminogen Activator

  • 产品介绍
  • merck millipore,默克密理博,CC4000,Urokinase-type Plasminogen Activator

    重要规格表

    主要应用 Entrez基因编号 品种 Uni Prot编号
    ACTNM_002658.2HumanP00749
    描述
    产品目录编号 CC4000
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Urokinase-type Plasminogen Activator
    概述 A thrombolytic agent that converts plasminogen to plasmin. A mixture of high molecular weight and low molecular weight urokinase.
    Alternate Names
    • uPA
    产品信息
    演示 Lyophilized from 200 mM manitol, 100 mM NaCl, 50 mM Tris-HCl, pH 7.5 and 0.1 % PEG.
    应用
    主要应用
    • Activity Assay
    生物信息
    纯度 Over 98%SDS-PAGE:

    High molecular weight urokinase (54 kD) 40%

    Low molecular weight urokinase (33 kD) 50%

    Transitory forms of urokinase 10%
    来源 Prepared from urine of healthy individuals
    品种 Human
    Entrez基因编号
    • NM_002658.2
    Entrez基因汇总 This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer disease and also with decreased affinity for fibrin-binding. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. This gene's proprotein is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.
    基因符号
    • Urokinase-type plasminogen activator chain B].
    • PLAU
    • UPA
    • URK
    • u-PA
    • uPA
    • ATF
    • EC 3.4.21.73 [Contains: Urokinase-type plasminogen activator long chain A
    • Urokinase-type plasminogen activator short chain A
    UniProt编号
    • P00749
    UniProt汇总 FUNCTION: SwissProt: P00749 # Specifically cleave the zymogen plasminogen to form the active enzyme plasmin.
    SIZE: 431 amino acids; 48525 Da
    SUBUNIT: Found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A which is cleaved to yield a short chain A. Binds LRP1B; binding is followed by internalization and degradation. Interacts with MRC2. Interacts with PLAUR.
    SUBCELLULAR LOCATION: Secreted.
    TISSUE SPECIFICITY: Expressed in the prostate gland and prostate cancers.
    PTM: Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.
    SIMILARITY: SwissProt: P00749 ## Belongs to the peptidase S1 family. & Contains 1 EGF-like domain. & Contains 1 kringle domain. & Contains 1 peptidase S1 domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Reconstitute using 200-400 μL dH2O. Store at -20°C. Following reconstitution, aliquot and freeze (-70°C). This product is stable for 2 year as supplied. Stock solutions are stable for up to 6 months at -70°C.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,CC4000,Urokinase-type Plasminogen Activator

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