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merck millipore,默克密理博,MAB3319,Anti-MMP-14 Antibody, catalytic domain, clone 114-6G6
产品名称：Anti-MMP-14 Antibody, catalytic domain, clone 114-6G6
产品型号：MAB3319
This Anti-MMP-14 Antibody, catalytic domain, clone 114-6G6 is validated for use in ELISA, WB, IH(P) for the detection of MMP-14.
merck millipore,默克密理博,MAB3319,Anti-MMP-14 Antibody, catalytic domain, clone 114-6G6
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, ELISA M Purified Monoclonal Antibody 描述 产品目录编号 MAB3319 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-MMP-14 Antibody, catalytic domain, clone 114-6G6 Alternate Names - MT1-MMP
产品信息 格式 Purified 演示 Liquid in 0.1 M sodium phosphate buffer, pH 7.0 containing 2% protease free bovine serum albumin. 应用 应用 This Anti-MMP-14 Antibody, catalytic domain, clone 114-6G6 is validated for use in ELISA, WB, IH(P) for the detection of MMP-14. 主要应用 - Western Blotting
- ELISA
应用说明 Immunoblotting: 8-20 μg/mL. 66+60kDa (Ueno et al., 1997)
Immunohistochemistry on paraffin-embedded tissue sections, use at 20 μg/mL concentration (see Ueno et al., 1997; Nakamura et al., 1999). Requires periodate-lysine-paraformaldehyde fixative (Namura et al., 1999) for 18-24 hrs. at 4°C.
EIA Optimal working dilutions must be determined by end user.生物信息 表位 catalytic domain 克隆 114-6G6 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 The antibody specifically reacts with human MT1-MMP. This is a purified mouse monoclonal antibody to an oligopeptide of REVPYAYIREGHEK (residue 160-173) on human membrane-type 1 matrix metalloproteinase (human MT1-MMP) and does not react with mouse or rat. However, this sequence is identical in mouse and rat MT1-MMP. For unknown reasons this antibody does not react on westerns to CC1043. 同种型 IgG1κ 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_004995.2
Entrez基因汇总 Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. 基因符号 - EC 3.4.24.80
- MMP14
- MTMMP1
- MMP-14
- MT1MMP
- MT1-MMP
- MMP-X1
非反应性品种 - Rat
- Mouse
- Pig
UniProt编号 - P50281
UniProt汇总 FUNCTION: SwissProt: P50281 # Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface.
COFACTOR: Binds 1 zinc ion per subunit (By similarity). & Calcium (By similarity).
SIZE: 582 amino acids; 65884 Da
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
TISSUE SPECIFICITY: In stromal cells of colon, breast, and head and neck.
DOMAIN: SwissProt: P50281 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains.产品使用声明 销售限制 This product is not available for sale in Japan. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
- Manufactured by Daiichi Fine Chemical Co., Ltd
储存和货运信息 存储条件 Maintain frozen at -20°C in undiluted aliquots for up to 12 months. 包装信息 数量 100 µg
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