- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,04-588,Anti-Cytokeratin 8 Antibody, rabbit monoclonal, clone E432
产品名称：Anti-Cytokeratin 8 Antibody, rabbit monoclonal, clone E432
产品型号：04-588
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect Cytokeratin 8 using this Anti-Cytokeratin 8 A More>>
merck millipore,默克密理博,04-588,Anti-Cytokeratin 8 Antibody, rabbit monoclonal, clone E432
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H ICC, FC, WB Rb Purified Monoclonal Antibody 描述 产品目录编号 04-588 品牌系列 Upstate
商名 - Upstate
描述 Anti-Cytokeratin 8 Antibody, rabbit monoclonal, clone E432 背景信息 Keratin polypeptides 8 and 18 (K8/18) are intermediate filament phosphoglycoproteins that are expressed preferentially in glandular epithelia. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells (1-3). Together with actin microfilaments and microtubules, keratin filaments make up the cytoskeletons of vertebrate epithelial cells, forming alpha-helical coiled-coil dimers which associate laterally and end-to-end to form 10-nm diameter filaments (4). 产品信息 格式 Purified 演示 Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. 应用 应用 Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect Cytokeratin 8 using this Anti-Cytokeratin 8 Antibody, Rabbit, clone E432 validated for use in FC, WB, IC, IH(P). 主要应用 - Immunocytochemistry
- Flow Cytometry
- Western Blotting
应用说明 WB: 1:500
IHC: 1:250-1:500 (Paraffin-embedded stomach carcinoma)
ICC: 1:50
Flow Cytometry: 1:20生物信息 免疫原品种 A synthetic peptide corresponding to residues surrounding Ser73 of human Cytokeratin 8. 克隆 E432 宿主 Rabbit 特异性 Recognizes Human, Mouse Cytokeratin 8. 品种反应性 MouseHuman Species Reactivity Note Human, Mouse (positive control: A431 cell lysate) 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002273.2
基因符号 - CARD2
- KRT8
- Cytokeratin-8
- Keratin-8
- K2C8
- CYK8
- CK-8
- KO
- K8
- CK8
纯化方法 Protein A purfied UniProt编号 - P05787
UniProt汇总 FUNCTION: SwissProt: P05787 # Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
SIZE: 483 amino acids; 53704 Da
SUBUNIT: Heterotetramer of two type I and two type II keratins. keratin-8 associates with keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
PTM: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
DISEASE:SwissProt: P05787 # Defects in KRT8 are a cause of cryptogenic cirrhosis [MIM:215600].
SIMILARITY: SwissProt: P05787 ## Belongs to the intermediate filament family.
MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at -20 °C. Stable for 12 months from date of receipt. 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,ST1529,Anti-HTT Mouse mAb (3F1)
下一件merck millipore产品：merck millipore,默克密理博,AB3914,Anti-SMC3 Antibody
相关产品
merck millipore,默克密理博,MAB303,Anti-Acetylcholinesterase Antibody, clone AE-1
merck millipore,默克密理博,07-461,Anti-phospho-MEK1 (Ser218/222)/MEK2 (Ser222/226) Antibody
merck millipore,默克密理博,AB9042,Anti-Brain Derived Neurotrophic Factor Antibody, pro
merck millipore,默克密理博,MAB3319,Anti-MMP-14 Antibody, catalytic domain, clone 114-6G6
merck millipore,默克密理博,ST1529,Anti-HTT Mouse mAb (3F1)
merck millipore,默克密理博,AB3914,Anti-SMC3 Antibody
merck millipore,默克密理博,07-353,Anti-acetyl-Histone H3 (Lys14) Antibody
merck millipore,默克密理博,341576,Fibrinogen, Human Plasma
merck millipore,默克密理博,70646,T7Select Human Lung cDNA Library
merck millipore,默克密理博,05-1336,Anti-phospho-Histone H3 (Ser10) Antibody, clone CMA312