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merck millipore,默克密理博,07-461,Anti-phospho-MEK1 (Ser218/222)/MEK2 (Ser222/226) Antibody
产品名称：Anti-phospho-MEK1 (Ser218/222)/MEK2 (Ser222/226) Antibody
产品型号：07-461
Anti-phospho-MEK1 (Ser218/222)/MEK2 (Ser222/226) Antibody detects level of phospho-MEK1 (Ser218/222)/MEK2 (Ser222/226) & has been published & validated for use in WB.
merck millipore,默克密理博,07-461,Anti-phospho-MEK1 (Ser218/222)/MEK2 (Ser222/226) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-461 Replaces 04-1017 品牌系列 Upstate
商名 - Upstate
描述 Anti-phospho-MEK1 (Ser218/222)/MEK2 (Ser222/226) Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl and 0.05% sodium azide. 应用 应用 Anti-phospho-MEK1 (Ser218/222)/MEK2 (Ser222/226) Antibody detects level of phospho-MEK1 (Ser218/222)/MEK2 (Ser222/226) & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Peptide corresponding to residues surrounding 218 and 222 of human MEK1. 宿主 Rabbit 特异性 MEK1/MEK2 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002755, NM_030662
Entrez基因汇总 The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. 基因符号 - MEK1
- MAP2K1
- PRKMK1
- MKK1
- MAPKK1
修改 - Phosphorylation
纯化方法 Protein A purfied UniProt编号 - Q02750
UniProt汇总 FUNCTION: SwissProt: Q02750 # Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.
SIZE: 393 amino acids; 43439 Da
SUBUNIT: Interacts with MORG1 (By similarity). Interacts with Yersinia yopJ.
PTM: Phosphorylation on Ser/Thr by MAP kinase kinase kinases (RAF or MEKK1) regulates positively the kinase activity. & Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
DISEASE: SwissProt: Q02750 # Defects in MAP2K1 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio- cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.
SIMILARITY: SwissProt: Q02750 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by immunoblot in RIPA lysates from PC-12 cells treated with B-Raf. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 200 µg
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