merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB3308,Anti-MMP-2 Antibody, a.a. 468-483 hMMP2, clone 42-5D11

  • merck millipore,默克密理博,MAB3308,Anti-MMP-2 Antibody, a.a. 468-483 hMMP2, clone 42-5D11

    产品名称：Anti-MMP-2 Antibody, a.a. 468-483 hMMP2, clone 42-5D11
    产品型号：MAB3308
    This Anti-MMP-2 Antibody, a.a. 468-483 hMMP2, clone 42-5D11 is validated for use in ELISA, IH(P), WB for the detection of MMP-2.

    merck millipore,默克密理博,MAB3308,Anti-MMP-2 Antibody, a.a. 468-483 hMMP2, clone 42-5D11

  • 产品介绍
  • merck millipore,默克密理博,MAB3308,Anti-MMP-2 Antibody, a.a. 468-483 hMMP2, clone 42-5D11

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Rb, B, Eq, H, M, Po, RWB, ELISAMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB3308
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-MMP-2 Antibody, a.a. 468-483 hMMP2, clone 42-5D11
    Alternate Names
    • 72 kDa Type IV Collagenase
    • Gelatinase A
    背景信息 The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane-bound zinc endopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.
    MMP2, also known as Gelatinase A, is a type IV collagenase that specifically cleaves type IV collagen, the major structural component of basement membranes. The metastatic potential of tumor cells has been found to correlate with the activity of this enzyme.
    产品信息
    格式 Purified
    控制
    • Lung, nerve, and various soft tissue tumors
    演示 Liquid in 0.1 M sodium phosphate buffer, pH 7.0 containing 2% protease free bovine Serum albumin.
    应用
    应用 This Anti-MMP-2 Antibody, a.a. 468-483 hMMP2, clone 42-5D11 is validated for use in ELISA, IH(P), WB for the detection of MMP-2.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Immunoblotting 1-5 μg/mL

    Immunohistochemistry on frozen and paraffin-embedded tissues using PLP fixation: 1-5 μg/mL (has not been tested in traditional formalin fixed tissues)

    ElA
    生物信息
    免疫原品种 Synthetic oligopeptide corresponding to amino acid residue 468-483 (VTPRDKPMGPLLVATF) of human matrix metalloproteinase 2 (human MMP-2, gelatinase A).
    表位 a.a. 468-483 hMMP2
    克隆 42-5D11
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Specifically reacts with precursor and active forms of human MMP-2. Does not cross react with human MMP-1, -3, -9, or -13. Also reacts with rat, mouse, and bovine MMP2, other species not tested.
    同种型 IgG1κ
    品种反应性 RabbitBovineHorseHumanMousePigRat
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_004530.2
    Entrez基因汇总 Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome.
    基因符号
    • EC 3.4.24.24
    • MMP2
    • TBE-1
    • CLG4A
    • CLG4
    • MMP-II
    • MONA
    • MMP-2
    纯化方法 Protein A purfied
    UniProt编号
    • P08253
    UniProt汇总 FUNCTION: SwissProt: P08253 # In addition to gelatin and collagens, it cleaves KiSS1 at a Gly- -Leu bond.
    COFACTOR: Binds 4 calcium ions per subunit. & Binds 2 zinc ions per subunit.
    SIZE: 660 amino acids; 73882 Da
    SUBUNIT: Ligand for integrin alpha-V/beta-3.
    TISSUE SPECIFICITY: Produced by normal skin fibroblasts.
    DOMAIN: SwissProt: P08253 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    PTM: The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT- MMP3).
    DISEASE: SwissProt: P08253 # Defects in MMP2 are the cause of multicentric osteolysis nodulosis and arthropathy (MONA) [MIM:605156]. Inherited osteolyses or 'vanishing bone' syndromes are rare disorders of unknown etiology characterized by destruction and resorption of affected bones. MONA is an autosomal recessive osteolysis with multicentric involvement characterized by carpal and tarsal resorption, crippling arthritic changes, marked osteoporosis, palmar and plantar subcutaneous nodules and distinctive facies. & Defects in MMP2 are the cause of Winchester syndrome [MIM:277950]. Winchester syndrome is an autosomal recessive osteolysis syndrome. Winchester syndrome is severe with generalized osteolysis and osteopenia. Subcutaneous nodules are usually absent. Winchester syndrome has been associated with a number of additional features including coarse face, corneal opacities, patches of thickened, hyperpigmented skin, hypertrichosis and gum hypertrophy. However, these features are not always present and have occasionally been observed in other osteolysis syndromes. The clinical and molecular findings suggest that Winchester syndrome and MONA are allelic disorders that form a continuous clinical spectrum.
    SIMILARITY: Belongs to the peptidase M10A family. & Contains 3 fibronectin type-II domains. & Contains 4 hemopexin-like domains.
    产品使用声明
    销售限制 This product is not available for sale in Japan.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    • Manufactured by Daiichi Fine Chemical Co., Ltd
    储存和货运信息
    存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB3308,Anti-MMP-2 Antibody, a.a. 468-483 hMMP2, clone 42-5D11

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