merck millipore,默克密理博,MAB308,Anti-Dopamine β Hydroxylase Antibody, clone 4F10.2

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merck millipore,默克密理博,MAB308,Anti-Dopamine β Hydroxylase Antibody, clone 4F10.2
产品名称：Anti-Dopamine β Hydroxylase Antibody, clone 4F10.2
产品型号：MAB308
Anti-Dopamine β Hydroxylase Antibody, clone 4F10.2 detects level of Dopamine β Hydroxylase & has been published & validated for use in IH, IH(P) & IF.

merck millipore,默克密理博,MAB308,Anti-Dopamine β Hydroxylase Antibody, clone 4F10.2

产品介绍

merck millipore,默克密理博,MAB308,Anti-Dopamine β Hydroxylase Antibody, clone 4F10.2

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
Sh, B, R	IHC	M	Ascites	Monoclonal Antibody

描述
产品目录编号	MAB308
Replaces	MAB394-250UG; MAB394-100UG; MAB394-25UG
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Dopamine β Hydroxylase Antibody, clone 4F10.2
Alternate Names	DBH
背景信息	Dopamine Beta Hydroxylase (DBH), the structural locus encoding DβH enzyme, is a major quantitative trait locus influencing plasma DβH activity, with one single nucleotide polymorphism (SNP) accounting for up to 50% of the variance. Mutations at DBH appear to be responsible for the rare syndrome of DβH deficiency. It functions as the only enzyme involved in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine and epinephrine the only transmitters synthesized inside vesicles. It is expressed in noradrenergic nerve terminals of the central and peripheral nervous systems, as well as in chromaffin cells of the adrenal medulla.

产品信息
格式	Ascites
控制	Brain (Striatum/Substantia Nigra)
演示	Ascites mouse monoclonal IgG1 in liquid with 0.1% sodium azide.

应用
应用	Anti-Dopamine β Hydroxylase Antibody, clone 4F10.2 detects level of Dopamine β Hydroxylase & has been published & validated for use in IH, IH(P) & IF.
主要应用	Immunohistochemistry
应用说明	Indirect immunofluorescence: 1:300-1:500 dilution of a previous lot was used on rat brain tissue. Optimal working dilutions must be determined by the end user. Immunohistochemistry(paraffin): Representative images from a previous lot. Optimal Staining With Citrate Buffer, pH 6.0, Epitope Retrieval: Rat Spinal Cord

生物信息
免疫原品种	Purified bovine DBH.
克隆	4F10.2
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	Dopamine beta hydroxylase (DBH).
同种型	IgG1
品种反应性	SheepBovineRat
Species Reactivity Note	Bovine, Rat and Sheep
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_000787.3
Entrez基因汇总	The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide.
基因符号	EC 1.14.17.1 [Contains: Soluble dopamine beta-hydroxylase]. DBH DBM
纯化方法	Unpurified
UniProt编号	P09172
UniProt汇总	FUNCTION: SwissProt: P09172 # Conversion of dopamine to noradrenaline. COFACTOR: Binds 1 PQQ per subunit. & Binds 2 copper ions per subunit. SIZE: 617 amino acids; 69065 Da SUBUNIT: Homotetramer composed of two non-covalently bound disulfide-linked dimers. SUBCELLULAR LOCATION: Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. & Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single- pass type II membrane protein (Potential). DISEASE: SwissProt: P09172 # Defects in DBH are the cause of DBH deficiency [MIM:223360]; also called norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction. SIMILARITY: SwissProt: P09172 ## Belongs to the copper type II ascorbate-dependent monooxygenase family. & Contains 1 DOMON domain.

产品使用声明
质量保证	Immunohistochemistry(paraffin): Dopamine β Hydroxylase (cat. # MAB308) staining pattern/morphology in rat spinal cord. Tissue was pretreated with Citrate, pH 6.0. This lot of antibody was diluted to 1:300, using IHC-Select® Detection with HRP-DAB. Immunoreactivity is seen predominantly expressed in the dorsal root ganglia (DRG). Optimal Staining With Citrate Buffer, pH 6.0, Epitope Retrieval: Rat Spinal Cord
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品使用声明

质量保证

Immunohistochemistry(paraffin): Dopamine β Hydroxylase (cat. # MAB308) staining pattern/morphology in rat spinal cord. Tissue was pretreated with Citrate, pH 6.0. This lot of antibody was diluted to 1:300, using IHC-Select® Detection with HRP-DAB. Immunoreactivity is seen predominantly expressed in the dorsal root ganglia (DRG).

Optimal Staining With Citrate Buffer, pH 6.0, Epitope Retrieval: Rat Spinal Cord

使用声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.