merck millipore,默克密理愽
  • merck millipore,默克密理博,217505,CBP-CREB Interaction Inhibitor - CAS 92-78-4 - Calbiochem

  • merck millipore,默克密理博,217505,CBP-CREB Interaction Inhibitor - CAS 92-78-4 - Calbiochem

    产品名称：CBP-CREB Interaction Inhibitor - CAS 92-78-4 - Calbiochem
    产品型号：217505
    The CBP-CREB Interaction Inhibitor, also referenced under CAS 92-78-4, controls the biological activity of CBP-CREB.

    merck millipore,默克密理博,217505,CBP-CREB Interaction Inhibitor - CAS 92-78-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,217505,CBP-CREB Interaction Inhibitor - CAS 92-78-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₇H₁₂ClNO₂92-78-4
    描述
    概述 A cell-permeable naphthamide compound that effectively blocks the interaction between the KIX domain of CBP and the KID domain of CREB in HEK293T-based and cell-free Renilla luciferase (RLuc) complementation assays (IC50 = 2.26 and 2.9 µM, respectively) by directly binding to CBP's KIX domain (Kd ~8.6 µM using a recombinant KIX). Shown to inhibit CRE- (cAMP response element) dependent transcription activity induced by forskolin (Cat. No. 344270) in a HEK293T-based RLuc reporter assay (IC50 <2.5 µM), while exhibiting little effect against the KID-independent CREB-VP16 transcription activity. Also reported to inhibit the enzymatic activity of Firefly luciferase (IC50 ~1 µM), but not that of RLuc.
    产品目录编号 217505
    品牌系列 Calbiochem®
    同义词 Luciferase Inhibitor III, N-(4-Chlorophenyl)-3-hydroxy-2-naphthamide, KIX-KID Interaction Inhibitor
    参考
    参考 Li, B.X. and Xiao, X., 2009. ChemBioChem 10, 2721.
    Best, J.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 17622.
    产品信息
    CAS号 92-78-4
    形式 Beige solid
    Hill配方 C₁₇H₁₂ClNO₂
    化学配方 C₁₇H₁₂ClNO₂
    Molar Mass 297.7
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,217505,CBP-CREB Interaction Inhibitor - CAS 92-78-4 - Calbiochem

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