merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5630P,Anti-Ca++ Sensing Receptor Antibody

  • merck millipore,默克密理博,AB5630P,Anti-Ca++ Sensing Receptor Antibody

    产品名称：Anti-Ca++ Sensing Receptor Antibody
    产品型号：AB5630P
    This Anti-Ca++ Sensing Receptor Antibody is validated for use in ELISA, WB for the detection of Ca++ Sensing Receptor.

    merck millipore,默克密理博,AB5630P,Anti-Ca++ Sensing Receptor Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5630P,Anti-Ca++ Sensing Receptor Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, ELISARbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5630P
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Ca++ Sensing Receptor Antibody
    Alternate Names
    • CaSR
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Liquid in PBS containing 0.1% BSA
    应用
    应用 This Anti-Ca++ Sensing Receptor Antibody is validated for use in ELISA, WB for the detection of Ca++ Sensing Receptor.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Western blot: 1-10 μg/mL using ECL.

    ELISA: 0.5-1 μg/mL using 1 μg/mL control peptide (Cat. No. AG359) per well.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 A 20 amino acid peptide sequence near the C-terminus of human CaSR. The immunogen sequence is 90% conserved in rat/mouse and 85% in bovine.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes Calcium Sensing Receptor (CaSR).
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000388.2
    Entrez基因汇总 The calcium-sensing receptor (CASR) functions as a sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Mutations that inactivate CASR cause familial hypocalciuric hypercalcemia, whereas mutations that activate CASR are the cause of autosomal dominant hypocalcemia. An altenatively spliced transcript variant encoding 1088 aa has been found for this gene, but its full-length nature has not been defined.
    基因符号
    • CaSR
    • CASR
    • PCAR1
    • CAR
    • MGC138441
    • FIH
    • HHC1
    • NSHPT
    • HHC
    • GPRC2A
    • FHH
    UniProt编号
    • P41180
    UniProt汇总 FUNCTION: SwissProt: P41180 # Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system.
    SIZE: 1078 amino acids; 120674 Da
    SUBUNIT: Interacts with VCP and RNF19A.
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
    TISSUE SPECIFICITY: Found in kidney, but not in brain, lung, liver, heart, skeletal muscle, or placenta.
    PTM: N-glycosylated. & Ubiquitinated by RNF19A; which induces proteasomal degradation.
    DISEASE: SwissProt: P41180 # Defects in CASR are the cause of familial hypocalciuric hypercalcemia type 1 (FHH) [MIM:145980]; in which the receptor has reduced activity. FHH is characterized by altered calcium homeostasis. Affected individuals exhibit mild or modest hypercalcemia, relative hypocalciuria, and inappropriately normal PTH levels. & Defects in CASR are the cause of neonatal severe primary hyperparathyroidism (NSHPT) [MIM:239200]; in which the receptor has reduced activity. NSHPT is a rare autosomal recessive life- threatening disorder characterized by very high serum calcium concentrations, skeletal demineralization, and parathyroid hyperplasia. In some instances NSHPT has been demonstrated to be the homozygous form of FHH. & Defects in CASR are the cause of autosomal dominant hypoparathyroidism (FIH) [MIM:146200]. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps.
    SIMILARITY: SwissProt: P41180 ## Belongs to the G-protein coupled receptor 3 family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB5630P,Anti-Ca++ Sensing Receptor Antibody

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