merck millipore,默克密理博,MAB3060,Anti-Paxillin Antibody, clone 349

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merck millipore,默克密理博,MAB3060,Anti-Paxillin Antibody, clone 349
产品名称：Anti-Paxillin Antibody, clone 349
产品型号：MAB3060
Anti-Paxillin Antibody, clone 349 detects level of Paxillin & has been published & validated for use in ELISA, WB, IC, IH.

merck millipore,默克密理博,MAB3060,Anti-Paxillin Antibody, clone 349

产品介绍

merck millipore,默克密理博,MAB3060,Anti-Paxillin Antibody, clone 349

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, Ca, Ch, H, M	IHC, ELISA, WB, ICC	M	Purified	Monoclonal Antibody

描述
产品目录编号	MAB3060
Replaces	04-581
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Paxillin Antibody, clone 349

产品信息
格式	Purified
控制	POSITIVE CONTROL: For western blot, load 5-10 μg of whole cell lysate prepared from the human epidermoid carcinoma cell line, A431.
演示	Purified immunoglobulin. Liquid in aqueous buffered solution containing 0.09% sodium azide.

应用
应用	Anti-Paxillin Antibody, clone 349 detects level of Paxillin & has been published & validated for use in ELISA, WB, IC, IH.
主要应用	Immunohistochemistry ELISA Western Blotting Immunocytochemistry
应用说明	Western blot: 1:1,000-1:10,000 ELISA Immunohistochemistry 1:900 in Placenta Immunocytochemistry Immunoprecipitation Optimal working dilutions must be determined by end user.

生物信息
免疫原品种	Affinity purified phosphotyrosine-containing proteins from Rous sarcoma virus-transformed chick embryo fibroblasts.
克隆	349
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	Reacts strongly with two bands on Western blots of total cell lysate from chick embryo fibroblasts or rat brain. The lower molecular band is believed to be either an isoform or a degradation product of the 68 kD protein, since it is found also on SDS-PAGE of affinity-purified paxillin.
同种型	IgG1
品种反应性	RatCanineChickenHumanMouse
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_002859.1
基因符号	FLJ16691 PXN Paxillin. paxillin
UniProt编号	P49023
UniProt汇总	FUNCTION: SwissProt: P49023 # Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). SIZE: 591 amino acids; 64533 Da SUBUNIT: Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1 (By similarity). Binds DDEF2. Interacts with unphosphorylated ITGA4. Interacts with RNF5. PTM: Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. SIMILARITY: SwissProt: P49023 ## Belongs to the paxillin family. & Contains 4 LIM zinc-binding domains.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.

储存和货运信息

存储条件

Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.

During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.